tert-butyl 2-(7-(5-(3-cyano-5-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate

Base Information

Chemical Name:tert-butyl 2-(7-(5-(3-cyano-5-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate
CAS No.:1174512-62-9
Molecular Formula:C₂₇H₂₃F₃N₄O₄
Molecular Weight:524.499
Hs Code.:

Synonyms:tert-butyl 2-(7-(5-(3-cyano-5-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate

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Chemical Property of tert-butyl 2-(7-(5-(3-cyano-5-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate

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Technology Process of tert-butyl 2-(7-(5-(3-cyano-5-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate

There total 8 articles about tert-butyl 2-(7-(5-(3-cyano-5-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1163142-00-4
3-cyano-5-(trifluoromethoxy)benzoyl chloride

: 1174512-15-2
tert-butyl 2-(7-(N'-hydroxycarbamimidoyl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate

: 1174512-62-9
tert-butyl 2-(7-(5-(3-cyano-5-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate

Guidance literature:: With triethylamine; In 1,4-dioxane; at 75 ℃; for 3.5h; Product distribution / selectivity;

Reference yield:

: 453565-91-8
3-cyano-5-(trifluoromethoxy)benzoic acid

: 1174512-15-2
tert-butyl 2-(7-(N'-hydroxycarbamimidoyl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate

: 1174512-62-9
tert-butyl 2-(7-(5-(3-cyano-5-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate

Guidance literature:: 3-cyano-5-(trifluoromethoxy)benzoic acid; With 1,1'-carbonyldiimidazole; In acetonitrile; at 20 - 60 ℃;

tert-butyl 2-(7-(N'-hydroxycarbamimidoyl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate; With 2-hydroxypyridin; In acetonitrile; at 45 - 80 ℃; Product distribution / selectivity;

Reference yield:

: 16732-70-0
ethyl 5-bromoindolecarboxylate

: 1174512-62-9
tert-butyl 2-(7-(5-(3-cyano-5-(trifluoromethoxy)phenyl)-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1H-pyrrolo[1,2-a]indol-1-yl)acetate

Guidance literature:: Multi-step reaction with 6 steps

1: sodium hydride / toluene; mineral oil / 48 h / 110 °C

2: 1-methyl-pyrrolidin-2-one / 2 h / 200 °C / Sealed tube; Microwave irradiation

3: tetrahydrofuran / 22 h / 65 °C

4: hydrogen / palladium on carbon / ethyl acetate / 22 h / 3620.13 Torr / Inert atmosphere

5: hydroxylamine / ethanol; water / 4 h / 70 °C / Sealed tube

6: triethylamine / 1,4-dioxane / 3.5 h / 75 °C

With 1-methyl-pyrrolidin-2-one; hydrogen; hydroxylamine; sodium hydride; triethylamine; palladium on carbon; In tetrahydrofuran; 1,4-dioxane; ethanol; water; ethyl acetate; toluene; mineral oil;