phenylmethyl 4-{3-[5-chloro-2-(4-chlorophenyl )-1-methyl-1H-indol-3-yl]-1-oxopropyl}-3-oxo-1-piperazinecarboxylate

Base Information

Chemical Name:phenylmethyl 4-{3-[5-chloro-2-(4-chlorophenyl )-1-methyl-1H-indol-3-yl]-1-oxopropyl}-3-oxo-1-piperazinecarboxylate
CAS No.:290832-15-4
Molecular Formula:C₃₀H₂₇Cl₂N₃O₄
Molecular Weight:564.468
Hs Code.:

Synonyms:phenylmethyl 4-{3-[5-chloro-2-(4-chlorophenyl )-1-methyl-1H-indol-3-yl]-1-oxopropyl}-3-oxo-1-piperazinecarboxylate

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Chemical Property of phenylmethyl 4-{3-[5-chloro-2-(4-chlorophenyl )-1-methyl-1H-indol-3-yl]-1-oxopropyl}-3-oxo-1-piperazinecarboxylate

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Technology Process of phenylmethyl 4-{3-[5-chloro-2-(4-chlorophenyl )-1-methyl-1H-indol-3-yl]-1-oxopropyl}-3-oxo-1-piperazinecarboxylate

There total 3 articles about phenylmethyl 4-{3-[5-chloro-2-(4-chlorophenyl )-1-methyl-1H-indol-3-yl]-1-oxopropyl}-3-oxo-1-piperazinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5-chloro-2-(4-chlorophenyl)-1-methyl-1H-indole-3-propanoyl chloride

: 78818-15-2
4-benzyloxycarbonylpiperazin-2-one

: 290832-15-4
phenylmethyl 4-{3-[5-chloro-2-(4-chlorophenyl )-1-methyl-1H-indol-3-yl]-1-oxopropyl}-3-oxo-1-piperazinecarboxylate

Guidance literature:: 4-benzyloxycarbonylpiperazin-2-one; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 0.5h;

5-chloro-2-(4-chlorophenyl)-1-methyl-1H-indole-3-propanoyl chloride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃;

Reference yield:

: 290832-34-7
5-chloro-2-(4-chlorophenyl)-1H-indole-3-propanoic acid

: 290832-15-4
phenylmethyl 4-{3-[5-chloro-2-(4-chlorophenyl )-1-methyl-1H-indol-3-yl]-1-oxopropyl}-3-oxo-1-piperazinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.5 h / 0 °C

1.2: 0.5 h / 20 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 2 h / 0 - 20 °C

3.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.5 h / 20 °C

3.2: 20 °C

With oxalyl dichloride; sodium hydride; N,N-dimethyl-formamide; In N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 290832-35-8
5-chloro-2-(4-chlorophenyl)-1-methyl-1H-indole-3-propanoic acid

: 290832-15-4
phenylmethyl 4-{3-[5-chloro-2-(4-chlorophenyl )-1-methyl-1H-indol-3-yl]-1-oxopropyl}-3-oxo-1-piperazinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: oxalyl dichloride; N,N-dimethyl-formamide / toluene / 2 h / 0 - 20 °C

2.1: sodium hydride / mineral oil; N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 20 °C

With oxalyl dichloride; sodium hydride; N,N-dimethyl-formamide; In N,N-dimethyl-formamide; toluene; mineral oil;