Technology Process of 2',6'-dimethylphenyl (2S,3S,4R,5R,6S)-3,5-isopropylidenedioxy-2,4,6-trimethyl-7-oxo-1-heptanoate
There total 10 articles about 2',6'-dimethylphenyl (2S,3S,4R,5R,6S)-3,5-isopropylidenedioxy-2,4,6-trimethyl-7-oxo-1-heptanoate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
oxalyl dichloride; dimethyl sulfoxide;
In
dichloromethane;
at -78 ℃;
for 0.333333h;
DOI:10.1002/hlca.19860690311
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 52 percent / (iPr)2NH, BuLi / tetrahydrofuran; hexane / 1 h / -78 °C
2: 78 percent / conc. HCl / tetrahydrofuran / 0.25 h / Ambient temperature
3: 99 percent / imidazole / dimethylformamide / 2 h / Ambient temperature
4: 91 percent / Amberlyst 15 / methanol
5: 96 percent / Bu4NF / tetrahydrofuran / 0.17 h
6: 96 percent / (COCl)2, DMSO / CH2Cl2 / 0.33 h / -78 °C
With
1H-imidazole; hydrogenchloride; n-butyllithium; Amberlyst 15; oxalyl dichloride; tetrabutyl ammonium fluoride; dimethyl sulfoxide; diisopropylamine;
In
tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19860690311
- Guidance literature:
-
Multi-step reaction with 9 steps
1: BH3*Me2S / tetrahydrofuran / 1.) 0 deg C, 20 min, 2.) RT, 2 h
2: 50 percent / Amberlyst 15 / methanol / Ambient temperature
3: 86 percent / DIBAH / toluene; hexane / 0.83 h / -78 °C
4: 52 percent / (iPr)2NH, BuLi / tetrahydrofuran; hexane / 1 h / -78 °C
5: 78 percent / conc. HCl / tetrahydrofuran / 0.25 h / Ambient temperature
6: 99 percent / imidazole / dimethylformamide / 2 h / Ambient temperature
7: 91 percent / Amberlyst 15 / methanol
8: 96 percent / Bu4NF / tetrahydrofuran / 0.17 h
9: 96 percent / (COCl)2, DMSO / CH2Cl2 / 0.33 h / -78 °C
With
1H-imidazole; hydrogenchloride; n-butyllithium; Amberlyst 15; oxalyl dichloride; dimethylsulfide borane complex; tetrabutyl ammonium fluoride; diisobutylaluminium hydride; dimethyl sulfoxide; diisopropylamine;
In
tetrahydrofuran; methanol; hexane; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.1002/hlca.19860690311
