2-acetylamino-N-{1-[1-benzylcarbamoyl-2-(tert-butyl-dimethyl-silanyloxy)-ethylcarbamoyl]-2-phenyl-ethyl}-3-methyl-butyramide

Base Information

Chemical Name:2-acetylamino-N-{1-[1-benzylcarbamoyl-2-(tert-butyl-dimethyl-silanyloxy)-ethylcarbamoyl]-2-phenyl-ethyl}-3-methyl-butyramide
CAS No.:872983-84-1
Molecular Formula:C₃₂H₄₈N₄O₅Si
Molecular Weight:596.842
Hs Code.:

2-acetylamino-<i>N</i>-{1-[1-benzylcarbamoyl-2-(<i>tert</i>-butyl-dimethyl-silanyloxy)-ethylcarbamoyl]-2-phenyl-ethyl}-3-methyl-butyramide

Synonyms:2-acetylamino-N-{1-[1-benzylcarbamoyl-2-(tert-butyl-dimethyl-silanyloxy)-ethylcarbamoyl]-2-phenyl-ethyl}-3-methyl-butyramide

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Chemical Property of 2-acetylamino-N-{1-[1-benzylcarbamoyl-2-(tert-butyl-dimethyl-silanyloxy)-ethylcarbamoyl]-2-phenyl-ethyl}-3-methyl-butyramide

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Technology Process of 2-acetylamino-N-{1-[1-benzylcarbamoyl-2-(tert-butyl-dimethyl-silanyloxy)-ethylcarbamoyl]-2-phenyl-ethyl}-3-methyl-butyramide

There total 6 articles about 2-acetylamino-N-{1-[1-benzylcarbamoyl-2-(tert-butyl-dimethyl-silanyloxy)-ethylcarbamoyl]-2-phenyl-ethyl}-3-methyl-butyramide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2-amino-N-{1-[1-benzylcarbamoyl-2-(tert-butyl-dimethyl-silanyloxy)-ethylcarbamoyl]-2-phenyl-ethyl}-3-methyl-butyramide

: 108-24-7
acetic anhydride

: 872983-84-1
2-acetylamino-N-{1-[1-benzylcarbamoyl-2-(tert-butyl-dimethyl-silanyloxy)-ethylcarbamoyl]-2-phenyl-ethyl}-3-methyl-butyramide

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 0 ℃;
DOI:10.1016/j.bmc.2005.08.019

Reference yield:

: 872983-80-7
2-[2-(2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-3-phenyl-propionylamino]-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid methyl ester

: 872983-84-1
2-acetylamino-N-{1-[1-benzylcarbamoyl-2-(tert-butyl-dimethyl-silanyloxy)-ethylcarbamoyl]-2-phenyl-ethyl}-3-methyl-butyramide

Guidance literature:: Multi-step reaction with 4 steps

1: 91 percent / LiOH / tetrahydrofuran; H₂O / 3 h / 0 °C

2: 57 percent / 1-hydroxy-1H-benzotriazole; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide HCl; triethylamine / CH₂Cl₂ / cooling

3: trifluoroacetic acid / CH₂Cl₂ / 0 °C

4: 0.08 g / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 0 °C

With dmap; lithium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; dichloromethane; water;
DOI:10.1016/j.bmc.2005.08.019

Reference yield:

: 872983-82-9
2-[2-(2-tert-butoxycarbonylamino-3-methyl-butyrylamino)-3-phenyl-propionylamino]-3-(tert-butyl-dimethyl-silanyloxy)-propionic acid

: 872983-84-1
2-acetylamino-N-{1-[1-benzylcarbamoyl-2-(tert-butyl-dimethyl-silanyloxy)-ethylcarbamoyl]-2-phenyl-ethyl}-3-methyl-butyramide

Guidance literature:: Multi-step reaction with 3 steps

1: 57 percent / 1-hydroxy-1H-benzotriazole; 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide HCl; triethylamine / CH₂Cl₂ / cooling

2: trifluoroacetic acid / CH₂Cl₂ / 0 °C

3: 0.08 g / triethylamine; 4-(dimethylamino)pyridine / CH₂Cl₂ / 0 °C

With dmap; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/j.bmc.2005.08.019