α-<1-methyl-3-(tetrahydro-2H-pyran-2-yl)-1-propenyl>benzenemethanol

Base Information

• Chemical Name: α-<1-methyl-3-(tetrahydro-2H-pyran-2-yl)-1-propenyl>benzenemethanol
• CAS No.: 80317-48-2
• Molecular Formula: C₁₆H₂₂O₂
• Molecular Weight: 246.349
• Mol file: 80317-48-2.mol

Synonyms:α-<1-methyl-3-(tetrahydro-2H-pyran-2-yl)-1-propenyl>benzenemethanol

Chemical Property of α-<1-methyl-3-(tetrahydro-2H-pyran-2-yl)-1-propenyl>benzenemethanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of α-<1-methyl-3-(tetrahydro-2H-pyran-2-yl)-1-propenyl>benzenemethanol

There total 6 articles about α-<1-methyl-3-(tetrahydro-2H-pyran-2-yl)-1-propenyl>benzenemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-Methyl-2-[(E)-3-methyl-4-phenyl-1-(tetrahydro-pyran-2-yl)-but-3-ene-2-sulfinyl]-1H-imidazole → α-<1-methyl-3-(tetrahydro-2H-pyran-2-yl)-1-propenyl>benzenemethanol (80317-48-2)

Guidance literature:

With methanol; diethylamine; at 0 ℃; for 23h; Yield given;

DOI:10.1021/jo00344a013

Reference yield:

2-methyl-3-phenylprop-2-en-1-ol (1504-55-8) → α-<1-methyl-3-(tetrahydro-2H-pyran-2-yl)-1-propenyl>benzenemethanol (80317-48-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 87 percent / conc. HCl / 1 h

2: 1.) CH₃ONa / 1.) CH₃OH, 5 min, 2.) CH₃OH, RT, 14 h

3: 1.) n-BuLi / 1.) hexane, THF, -78 deg C, 10 min, 2.) hexane, THF, from -78 deg C to RT, 1 h

4: 80-90percent m-chloroperoxybenzoic acid / CH₂Cl₂ / 0.17 h / 0 °C

5: diethylamine, methanol / 23 h / 0 °C

With hydrogenchloride; methanol; n-butyllithium; sodium methylate; diethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

DOI:10.1021/jo00344a013

Reference yield:

(3-chloro-2-methyl-1-propenyl)benzene (1507-88-6) → α-<1-methyl-3-(tetrahydro-2H-pyran-2-yl)-1-propenyl>benzenemethanol (80317-48-2)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) CH₃ONa / 1.) CH₃OH, 5 min, 2.) CH₃OH, RT, 14 h

2: 1.) n-BuLi / 1.) hexane, THF, -78 deg C, 10 min, 2.) hexane, THF, from -78 deg C to RT, 1 h

3: 80-90percent m-chloroperoxybenzoic acid / CH₂Cl₂ / 0.17 h / 0 °C

4: diethylamine, methanol / 23 h / 0 °C

With methanol; n-butyllithium; sodium methylate; diethylamine; 3-chloro-benzenecarboperoxoic acid; In dichloromethane;

DOI:10.1021/jo00344a013

upstream raw materials:

2-methyl-3-phenylprop-2-en-1-ol

(3-chloro-2-methyl-1-propenyl)benzene

1-methyl-2-<(2-methyl-3-phenyl-2-propenyl)thio>-1H-imidazole

1-methyl-2-<<2-methyl-3-phenyl-1-<(tetrahydro-2H-pyran-2-yl)methyl>-2-propenyl>thio>-1H-imidazole

Downstream raw materials:

(E)-2-methyl-1-phenyl-4-(tetrahydro-2H-pyran-2-yl)-2-buten-1-one