[2-((S)-3-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-1,3-dihydroxy-propyl)-phenyl]-piperidin-1-yl-methanone

Base Information

• Chemical Name: [2-((S)-3-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-1,3-dihydroxy-propyl)-phenyl]-piperidin-1-yl-methanone
• CAS No.: 184763-87-9
• Molecular Formula: C₃₂H₃₁ClN₂O₃
• Molecular Weight: 527.063

Synonyms:[2-((S)-3-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-1,3-dihydroxy-propyl)-phenyl]-piperidin-1-yl-methanone

Chemical Property of [2-((S)-3-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-1,3-dihydroxy-propyl)-phenyl]-piperidin-1-yl-methanone

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Technology Process of [2-((S)-3-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-1,3-dihydroxy-propyl)-phenyl]-piperidin-1-yl-methanone

There total 1 articles about [2-((S)-3-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-1,3-dihydroxy-propyl)-phenyl]-piperidin-1-yl-methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

piperidine (110-89-4) + 3-(2-{3-[2-(7-chloro-2-quinolinyl)-(E)-ethenyl]phenyl}-(S)-2-hydroxyethyl)-(R/S)-3H-isobenzofuran-1-one → [2-((S)-3-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-1,3-dihydroxy-propyl)-phenyl]-piperidin-1-yl-methanone (184763-87-9)

Guidance literature:

With methylmagnesium chloride; Yield given. Multistep reaction; 1.) THF, room temperature, 2.) THF, room temperature, 4 h;

DOI:10.1021/jo9615817

Reference yield: 28.0%

benzaldehyde dimethyl acetal (1125-88-8) + [2-((S)-3-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-1,3-dihydroxy-propyl)-phenyl]-piperidin-1-yl-methanone (184763-87-9) → [2-((2R,4R,6S)-6-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-2-phenyl-[1,3]dioxan-4-yl)-phenyl]-piperidin-1-yl-methanone (184764-41-8) + [2-((2R,4S,6S)-6-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-2-phenyl-[1,3]dioxan-4-yl)-phenyl]-piperidin-1-yl-methanone (184763-93-7)

Guidance literature:

With trichlorophosphate; In dichloromethane; at 0 ℃; for 18h;

DOI:10.1021/jo9615817

upstream raw materials:

piperidine

Downstream raw materials:

[2-((2R,4R,6S)-6-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-2-phenyl-[1,3]dioxan-4-yl)-phenyl]-piperidin-1-yl-methanone

[2-((2R,4S,6S)-6-{3-[(E)-2-(7-Chloro-quinolin-2-yl)-vinyl]-phenyl}-2-phenyl-[1,3]dioxan-4-yl)-phenyl]-piperidin-1-yl-methanone

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