(1R,4S)-1-<(9-Phenyl-9-fluorenyl)amino>-4-(hydroxymethyl)-2-cyclopentene

Base Information

Chemical Name:(1R,4S)-1-<(9-Phenyl-9-fluorenyl)amino>-4-(hydroxymethyl)-2-cyclopentene
CAS No.:154494-97-0
Molecular Formula:C₂₅H₂₃NO
Molecular Weight:353.464
Hs Code.:

Synonyms:(1R,4S)-1-<(9-Phenyl-9-fluorenyl)amino>-4-(hydroxymethyl)-2-cyclopentene

Suppliers and Price of (1R,4S)-1-<(9-Phenyl-9-fluorenyl)amino>-4-(hydroxymethyl)-2-cyclopentene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1R,4S)-1-<(9-Phenyl-9-fluorenyl)amino>-4-(hydroxymethyl)-2-cyclopentene

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1R,4S)-1-<(9-Phenyl-9-fluorenyl)amino>-4-(hydroxymethyl)-2-cyclopentene

There total 19 articles about (1R,4S)-1-<(9-Phenyl-9-fluorenyl)amino>-4-(hydroxymethyl)-2-cyclopentene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 154494-96-9
(1R,4S)-1-<(9-Phenyl-9-fluorenyl)amino>-4-<(methoxymethoxy)methyl>-2-cyclopentene

: 154494-97-0
(1R,4S)-1-<(9-Phenyl-9-fluorenyl)amino>-4-(hydroxymethyl)-2-cyclopentene

Guidance literature:: With pyridinium p-toluenesulfonate; In tert-butyl alcohol; for 3h; Heating;
DOI:10.1021/jo00081a019

Reference yield:

: 133473-09-3
methyl 2-[(9-phenylfluoren-9-yl)amino]-2-deoxy-3,4:5,6-di-O-isopropylidene-D-mannonate

: 154494-97-0
(1R,4S)-1-<(9-Phenyl-9-fluorenyl)amino>-4-(hydroxymethyl)-2-cyclopentene

Guidance literature:: Multi-step reaction with 19 steps

1: 86 percent / aq. HCl / diethyl ether / 3 h / 0 °C

2: 60 percent / O₂ / Pt / H₂O; ethyl acetate; propan-2-ol / 40 °C

3: 98 percent / K₂CO₃ / dimethylformamide / 12 h / Ambient temperature

4: pyridine / CH₂Cl₂ / 1 h

5: LiI*3H₂O / tetrahydrofuran; acetic acid / 48 h / Heating

6: 97 percent / KHMDS / tetrahydrofuran / 1 h / -78 °C

7: 96 percent / imidazole / dimethylformamide / 12 h / Ambient temperature

8: 92 percent / H₂ / 10percent Pt/C / ethyl acetate / 15 h / 2068.6 Torr

9: 95 percent / KHMDS / tetrahydrofuran / 0.5 h / -78 °C

10: 86 percent / NaBH₄ / propan-2-ol / 3 h / 0 °C

11: 97 percent / Et₃N / tetrahydrofuran / 2 h / 0 °C

12: 96 percent / NaH / tetrahydrofuran / 3 h / 0 °C

13: 95 percent / H₂ / 5percent Pt/C / ethyl acetate / 5 h

14: 95 percent / LAH / tetrahydrofuran / 2 h / 0 °C

15: 93 percent / diisopropylethylamine / CH₂Cl₂ / 3 h / Ambient temperature

16: 95 percent / Bu₄NF / tetrahydrofuran / 10 h

17: 97 percent / Et₃N / tetrahydrofuran / 2 h / 0 °C

18: 78 percent / NaH, 2-methoxyethanol / dimethylformamide / 5 h / 0 °C

19: 89 percent / PPTS / 2-methyl-propan-2-ol / 3 h / Heating

With pyridine; 1H-imidazole; hydrogenchloride; sodium tetrahydroborate; lithium aluminium tetrahydride; 2-methoxy-ethanol; tetrabutyl ammonium fluoride; hydrogen; oxygen; pyridinium p-toluenesulfonate; potassium hexamethylsilazane; sodium hydride; potassium carbonate; triethylamine; N-ethyl-N,N-diisopropylamine; lithium iodide; platinum on activated charcoal; platinum; In tetrahydrofuran; diethyl ether; dichloromethane; water; acetic acid; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; tert-butyl alcohol;
DOI:10.1021/jo00081a019

Reference yield:

: Dimethyl (2S,3S)-(E)-2-<(9-phenyl-9-fluorenyl)amino>-3-hydroxy-4-hexenedioate

: 154494-97-0
(1R,4S)-1-<(9-Phenyl-9-fluorenyl)amino>-4-(hydroxymethyl)-2-cyclopentene

Guidance literature:: Multi-step reaction with 13 steps

1: 96 percent / imidazole / dimethylformamide / 12 h / Ambient temperature

2: 92 percent / H₂ / 10percent Pt/C / ethyl acetate / 15 h / 2068.6 Torr

3: 95 percent / KHMDS / tetrahydrofuran / 0.5 h / -78 °C

4: 86 percent / NaBH₄ / propan-2-ol / 3 h / 0 °C

5: 97 percent / Et₃N / tetrahydrofuran / 2 h / 0 °C

6: 96 percent / NaH / tetrahydrofuran / 3 h / 0 °C

7: 95 percent / H₂ / 5percent Pt/C / ethyl acetate / 5 h

8: 95 percent / LAH / tetrahydrofuran / 2 h / 0 °C

9: 93 percent / diisopropylethylamine / CH₂Cl₂ / 3 h / Ambient temperature

10: 95 percent / Bu₄NF / tetrahydrofuran / 10 h

11: 97 percent / Et₃N / tetrahydrofuran / 2 h / 0 °C

12: 78 percent / NaH, 2-methoxyethanol / dimethylformamide / 5 h / 0 °C

13: 89 percent / PPTS / 2-methyl-propan-2-ol / 3 h / Heating

With 1H-imidazole; sodium tetrahydroborate; lithium aluminium tetrahydride; 2-methoxy-ethanol; tetrabutyl ammonium fluoride; hydrogen; pyridinium p-toluenesulfonate; potassium hexamethylsilazane; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; platinum on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol; tert-butyl alcohol;
DOI:10.1021/jo00081a019