N⁶-[(allyloxy)carbonyl]-2'-O-(tert-butyldimethylsilyl)-5'-O-(p,p'-dimethoxytrityl)adenosine 3'-(allyl N,N'-diisopropylphosphoramidite)

Base Information

• Chemical Name: N⁶-[(allyloxy)carbonyl]-2'-O-(tert-butyldimethylsilyl)-5'-O-(p,p'-dimethoxytrityl)adenosine 3'-(allyl N,N'-diisopropylphosphoramidite)
• CAS No.: 183378-43-0
• Molecular Formula: C₅₀H₆₇N₆O₉PSi
• Molecular Weight: 955.176

Synonyms:N⁶-[(allyloxy)carbonyl]-2'-O-(tert-butyldimethylsilyl)-5'-O-(p,p'-dimethoxytrityl)adenosine 3'-(allyl N,N'-diisopropylphosphoramidite)

Chemical Property of N⁶-[(allyloxy)carbonyl]-2'-O-(tert-butyldimethylsilyl)-5'-O-(p,p'-dimethoxytrityl)adenosine 3'-(allyl N,N'-diisopropylphosphoramidite)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N⁶-[(allyloxy)carbonyl]-2'-O-(tert-butyldimethylsilyl)-5'-O-(p,p'-dimethoxytrityl)adenosine 3'-(allyl N,N'-diisopropylphosphoramidite)

There total 6 articles about N⁶-[(allyloxy)carbonyl]-2'-O-(tert-butyldimethylsilyl)-5'-O-(p,p'-dimethoxytrityl)adenosine 3'-(allyl N,N'-diisopropylphosphoramidite) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(allyloxy)bis(diisopropylamino)phosphine (108554-72-9) + N6-[(allyloxy)carbonyl]-5'-O-(p,p'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)adenosine (185628-20-0) → N6-[(allyloxy)carbonyl]-2'-O-(tert-butyldimethylsilyl)-5'-O-(p,p'-dimethoxytrityl)adenosine 3'-(allyl N,N'-diisopropylphosphoramidite) (183378-43-0)

Guidance literature:

With N,N-diisopropylamine tetrazolide;

DOI:10.1055/s-1998-1822

Reference yield:

O2',O3',O5'-tris-trimethylsilanyl-adenosine (10457-15-5) → N6-[(allyloxy)carbonyl]-2'-O-(tert-butyldimethylsilyl)-5'-O-(p,p'-dimethoxytrityl)adenosine 3'-(allyl N,N'-diisopropylphosphoramidite) (183378-43-0)

Guidance literature:

Multi-step reaction with 5 steps

1: N-methylimidazole / CH₂Cl₂

2: 17.5 g / Et₃N / methanol / 12 h

3: 77 percent / pyridine; dimethylformamide / 0 - 20 °C

4: 33 percent / imidazole / dimethylformamide

5: 81 percent / diisopropylammonium tetrazolide / acetonitrile

With 1H-imidazole; 1-methyl-1H-imidazole; N,N-diisopropylamine tetrazolide; triethylamine; In pyridine; methanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 1: Acylation / 2: desilylation / 3: Etherification / 4: silylation / 5: Esterification;

DOI:10.1080/07328319908044842

Reference yield:

N6-[(allyloxy)carbonyl]adenosine (210684-23-4) → N6-[(allyloxy)carbonyl]-2'-O-(tert-butyldimethylsilyl)-5'-O-(p,p'-dimethoxytrityl)adenosine 3'-(allyl N,N'-diisopropylphosphoramidite) (183378-43-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 77 percent / pyridine; dimethylformamide / 0 - 20 °C

2: 33 percent / imidazole / dimethylformamide

3: 81 percent / diisopropylammonium tetrazolide / acetonitrile

With 1H-imidazole; N,N-diisopropylamine tetrazolide; In pyridine; N,N-dimethyl-formamide; acetonitrile; 1: Etherification / 2: silylation / 3: Esterification;

DOI:10.1080/07328319908044842

upstream raw materials:

(allyloxy)bis(diisopropylamino)phosphine

N⁶-[(allyloxy)carbonyl]-5'-O-(p,p'-dimethoxytrityl)-2'-O-(tert-butyldimethylsilyl)adenosine

O^2'_,O3'_,O5'-tris-trimethylsilanyl-adenosine

N⁶-[(allyloxy)carbonyl]adenosine

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 183378-43-0 N⁶-[(allyloxy)carbonyl]-2'-O-(tert-butyldimethylsilyl)-5'-O-(p,p'-dimethoxytrityl)adenosine 3'-(allyl N,N'-diisopropylphosphoramidite)

Send

Send

Metric Ton KG G Pound L ML

Send

Send