(S)-2-(2-{(R)-2-[(R)-3-(4-Acetoxy-phenyl)-2-acetylamino-propionylamino]-propionylamino}-acetylamino)-3-phenyl-propionic acid methyl ester

Base Information

Chemical Name:(S)-2-(2-{(R)-2-[(R)-3-(4-Acetoxy-phenyl)-2-acetylamino-propionylamino]-propionylamino}-acetylamino)-3-phenyl-propionic acid methyl ester
CAS No.:87242-58-8
Molecular Formula:C₂₈H₃₄N₄O₈
Molecular Weight:554.6
Hs Code.:

Synonyms:(S)-2-(2-{(R)-2-[(R)-3-(4-Acetoxy-phenyl)-2-acetylamino-propionylamino]-propionylamino}-acetylamino)-3-phenyl-propionic acid methyl ester

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Chemical Property of (S)-2-(2-{(R)-2-[(R)-3-(4-Acetoxy-phenyl)-2-acetylamino-propionylamino]-propionylamino}-acetylamino)-3-phenyl-propionic acid methyl ester

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Technology Process of (S)-2-(2-{(R)-2-[(R)-3-(4-Acetoxy-phenyl)-2-acetylamino-propionylamino]-propionylamino}-acetylamino)-3-phenyl-propionic acid methyl ester

There total 6 articles about (S)-2-(2-{(R)-2-[(R)-3-(4-Acetoxy-phenyl)-2-acetylamino-propionylamino]-propionylamino}-acetylamino)-3-phenyl-propionic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 87242-56-6
Ac-ΔTyr(Ac)-(R)-Ala-Gly-(S)-Phe-OMe

: 87242-58-8
(S)-2-(2-{(R)-2-[(R)-3-(4-Acetoxy-phenyl)-2-acetylamino-propionylamino]-propionylamino}-acetylamino)-3-phenyl-propionic acid methyl ester

Guidance literature:: With hydrogen; <(Ph-CAPP)Rh(norbornadiene)>(1+)*ClO4(1-); In ethanol; at 40 ℃; for 20h; under 3800 Torr; Yield given;
DOI:10.1016/S0040-4020(01)82412-1

Reference yield:

: 70529-59-8
N,O-diacetyltyrosine azlactone

: 87242-58-8
(S)-2-(2-{(R)-2-[(R)-3-(4-Acetoxy-phenyl)-2-acetylamino-propionylamino]-propionylamino}-acetylamino)-3-phenyl-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

2: 88 percent Turnov_. / H₂ / <(diPAMP)Rh(norbornadiene)>⁽¹⁺⁾*ClO₄^(1-) / ethanol / 24 h / 40 °C / 7600 Torr

3: NaOH

4: N,N-dicyclohexylcarbodiimide, 1-hydroxybenzotriazole

5: H₂ / <(Ph-CAAP)Rh(NBD)>⁽¹⁺⁾*ClO₄^(1-) / ethanol / 20 h / 40 °C / 3800 Torr

With sodium hydroxide; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; <(diPAMP)Rh(norbornadiene)>(1+)*ClO4(1-); <(Ph-CAPP)Rh(norbornadiene)>(1+)*ClO4(1-); In ethanol;
DOI:10.1016/S0040-4020(01)82412-1

Reference yield:

: 16227-22-8,16227-24-0,97372-81-1
glycyl-L-phenylalanine methyl ester

: 87242-58-8
(S)-2-(2-{(R)-2-[(R)-3-(4-Acetoxy-phenyl)-2-acetylamino-propionylamino]-propionylamino}-acetylamino)-3-phenyl-propionic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: N,N-dicyclohexylcarbodiimide, 1-hydroxybenzotriazole

2: H₂ / <(Ph-CAAP)Rh(NBD)>⁽¹⁺⁾*ClO₄^(1-) / ethanol / 20 h / 40 °C / 3800 Torr

With hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide; <(Ph-CAPP)Rh(norbornadiene)>(1+)*ClO4(1-); In ethanol;
DOI:10.1016/S0040-4020(01)82412-1