5-Methyl-3-p-tolylamino-1H-indole-2-carboxylic acid hydrazide

Base Information

• Chemical Name: 5-Methyl-3-p-tolylamino-1H-indole-2-carboxylic acid hydrazide
• CAS No.: 116931-14-7
• Molecular Formula: C₁₇H₁₈N₄O
• Molecular Weight: 294.356
• Mol file: 116931-14-7.mol

Synonyms:5-Methyl-3-p-tolylamino-1H-indole-2-carboxylic acid hydrazide

Chemical Property of 5-Methyl-3-p-tolylamino-1H-indole-2-carboxylic acid hydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 5-Methyl-3-p-tolylamino-1H-indole-2-carboxylic acid hydrazide

There total 3 articles about 5-Methyl-3-p-tolylamino-1H-indole-2-carboxylic acid hydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

ethyl 5-methyl-3-(p-tolylamino)-1H-indole-2-carboxylate (116931-02-3) → 5-Methyl-3-p-tolylamino-1H-indole-2-carboxylic acid hydrazide (116931-14-7)

Guidance literature:

With hydrazine hydrate; In ethanol; water; for 5h; Heating;

Reference yield:

3-bromo-5-methyl-1H-indole-2-carboxylic acid ethyl ester (93704-67-7) → 5-Methyl-3-p-tolylamino-1H-indole-2-carboxylic acid hydrazide (116931-14-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 49 percent / K₂CO₃, CuO / pyridine / 16 h / Heating

2: 62 percent / hydrazine hydrate / ethanol; H₂O / 5 h / Heating

With potassium carbonate; hydrazine hydrate; copper(II) oxide; In pyridine; ethanol; water;

Reference yield:

p-toluidine (106-49-0,12221-03-3) → 5-Methyl-3-p-tolylamino-1H-indole-2-carboxylic acid hydrazide (116931-14-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 49 percent / K₂CO₃, CuO / pyridine / 16 h / Heating

2: 62 percent / hydrazine hydrate / ethanol; H₂O / 5 h / Heating

With potassium carbonate; hydrazine hydrate; copper(II) oxide; In pyridine; ethanol; water;

upstream raw materials:

ethyl 5-methyl-3-(p-tolylamino)-1H-indole-2-carboxylate

3-bromo-5-methyl-1H-indole-2-carboxylic acid ethyl ester

p-toluidine

Downstream raw materials:

5-Methyl-3-p-tolylamino-1H-indole-2-carbonyl azide