4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(2-(pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamide

Base Information

Chemical Name:4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(2-(pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamide
CAS No.:1257628-64-0
Molecular Formula:C₂₉H₂₇F₃N₆O
Molecular Weight:532.568
Hs Code.:

Synonyms:4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(2-(pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(2-(pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamide

Chemical Property:

Purity/Quality:: ≥98% ^*data from raw suppliers

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Technology Process of 4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(2-(pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamide

There total 3 articles about 4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(2-(pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 694499-26-8
4-(4-methylpiperazin-1-ylmethyl)-3-trifluoromethylaniline

: 1429617-97-9
methyl 4-methyl-3-(pyrazolo[1,5-a]pyrimidin-6-ylethynyl)benzoate

: 1257628-64-0
4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(2-(pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamide

Guidance literature:: With potassium tert-butylate; In tetrahydrofuran; at -20 - 20 ℃; for 9h;
DOI:10.1080/14756366.2016.1250757

Reference yield:

: 90347-66-3
methyl 3-iodo-4-methylbenzoate

: 1257628-64-0
4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(2-(pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: copper(l) iodide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / acetonitrile / 2 h / 80 °C / Inert atmosphere

1.2: 3 h / 20 °C / Inert atmosphere

2.1: copper(l) iodide; N-ethyl-N,N-diisopropylamine; bis-triphenylphosphine-palladium(II) chloride / N,N-dimethyl-formamide / 80 °C / Inert atmosphere

3.1: potassium tert-butylate / tetrahydrofuran / 9 h / -20 - 20 °C

With bis-triphenylphosphine-palladium(II) chloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; copper(l) iodide; potassium tert-butylate; triethylamine; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile; 1.1: |Sonogashira Cross-Coupling;
DOI:10.1080/14756366.2016.1250757

Reference yield:

: 1257628-64-0
4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)-3-(2-(pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamide

Guidance literature:: With copper(l) iodide; palladium diacetate; N-ethyl-N,N-diisopropylamine; tricyclohexylphosphine; In N,N-dimethyl-formamide; at 60 ℃; for 12h; Inert atmosphere;