1-(4-(2,3-diaminopyridin-4-yloxy)-2-(methylthio)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

Base Information

• Chemical Name: 1-(4-(2,3-diaminopyridin-4-yloxy)-2-(methylthio)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea
• CAS No.: 884340-43-6
• Molecular Formula: C₂₀H₁₇ClF₃N₅O₂S
• Molecular Weight: 483.901

Synonyms:1-(4-(2,3-diaminopyridin-4-yloxy)-2-(methylthio)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

Chemical Property of 1-(4-(2,3-diaminopyridin-4-yloxy)-2-(methylthio)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

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Technology Process of 1-(4-(2,3-diaminopyridin-4-yloxy)-2-(methylthio)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

There total 1 articles about 1-(4-(2,3-diaminopyridin-4-yloxy)-2-(methylthio)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

1-[4-(2-amino-3-nitropyridin-4-yloxy)-2-(methylthio)phenyl]-3-[4-chloro-3-(trifluoromethyl)phenyl]urea (884340-42-5) → 1-(4-(2,3-diaminopyridin-4-yloxy)-2-(methylthio)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea (884340-43-6)

Guidance literature:

With iron; ammonium chloride; In ethanol; water; H₂₄ h;

Reference yield: 97.0%

1-(4-(2,3-diaminopyridin-4-yloxy)-2-(methylthio)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea (884340-43-6) + bis(trichloromethyl) carbonate (32315-10-9) → 1-(4-(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]pyridin-7-yloxy)-2-(methylthio)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea

Guidance literature:

With pyridine; In tetrahydrofuran; at 0 - 20 ℃;

DOI:10.1021/jm900242c

Reference yield: 12.0%

1-(4-(2,3-diaminopyridin-4-yloxy)-2-(methylthio)phenyl)-3-(4-chloro-3-(trifluoromethyl)phenyl)urea (884340-43-6) + oxalic acid diethyl ester (95-92-1) → 1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-(2,3-dioxo-1,2,3,4-tetrahydropyrido-[2,3-b]pyrazin-8-yloxy)-2-(methylthio)phenyl)urea (1163720-17-9)

Guidance literature:

In ethanol; toluene; at 20 ℃; Molecular sieve;

DOI:10.1021/jm100383b

upstream raw materials:

1-[4-(2-amino-3-nitropyridin-4-yloxy)-2-(methylthio)phenyl]-3-[4-chloro-3-(trifluoromethyl)phenyl]urea

Downstream raw materials:

1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-(2,3-dioxo-1,2,3,4-tetrahydropyrido-[2,3-b]pyrazin-8-yloxy)-2-(methylthio)phenyl)urea

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