N-[3-chloromethyl-3H-thiazol-2-(E/Z)ylidene]-4-(3,3-dimethylbutyrylamino)-3,5-difluorobenzamide

Base Information

Chemical Name:N-[3-chloromethyl-3H-thiazol-2-(E/Z)ylidene]-4-(3,3-dimethylbutyrylamino)-3,5-difluorobenzamide
CAS No.:913841-86-8
Molecular Formula:C₁₇H₁₈ClF₂N₃O₂S
Molecular Weight:401.865
Hs Code.:

Synonyms:N-[3-chloromethyl-3H-thiazol-2-(E/Z)ylidene]-4-(3,3-dimethylbutyrylamino)-3,5-difluorobenzamide

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Chemical Property of N-[3-chloromethyl-3H-thiazol-2-(E/Z)ylidene]-4-(3,3-dimethylbutyrylamino)-3,5-difluorobenzamide

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Technology Process of N-[3-chloromethyl-3H-thiazol-2-(E/Z)ylidene]-4-(3,3-dimethylbutyrylamino)-3,5-difluorobenzamide

There total 3 articles about N-[3-chloromethyl-3H-thiazol-2-(E/Z)ylidene]-4-(3,3-dimethylbutyrylamino)-3,5-difluorobenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 851202-49-8
4-(3,3-dimethylbutyrylamino)-3,5-difluoro-N-thiazol-2-ylbenzamide

: 22128-62-7
carbonochloridic acid, chloromethyl ester

: 913841-86-8
N-[3-chloromethyl-3H-thiazol-2-(E/Z)ylidene]-4-(3,3-dimethylbutyrylamino)-3,5-difluorobenzamide

Guidance literature:: 4-(3,3-dimethylbutyrylamino)-3,5-difluoro-N-thiazol-2-ylbenzamide; With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 20 ℃; for 1h;

carbonochloridic acid, chloromethyl ester; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃;
DOI:10.1021/jm1008659

Reference yield:

: 1262897-91-5
(2S,3S)-2-amino-3-methylpentanoic acid 2-[(E/Z)-4-(3,3-dimethylbutyrylamino)-3,5-difluorobenzoylimino]thiazol-3-ylmethyl ester hydrochloride

: 913841-86-8
N-[3-chloromethyl-3H-thiazol-2-(E/Z)ylidene]-4-(3,3-dimethylbutyrylamino)-3,5-difluorobenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 48 °C / pH 7

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

2.2: 0 - 20 °C

With sodium hydride; In N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm1008659

Reference yield:

: 913842-25-8
Lu AA₄₇₀₇₀

: 913841-86-8
N-[3-chloromethyl-3H-thiazol-2-(E/Z)ylidene]-4-(3,3-dimethylbutyrylamino)-3,5-difluorobenzamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 48 °C

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 1 h / 20 °C

2.2: 0 - 20 °C

With sodium hydride; In N,N-dimethyl-formamide; mineral oil;
DOI:10.1021/jm1008659