(+/-)-trans-2-(4-chlorophenyl)-N-methyltetrahydrothiopyran-2-carbothioamide-1-oxide

Base Information

Chemical Name:(+/-)-trans-2-(4-chlorophenyl)-N-methyltetrahydrothiopyran-2-carbothioamide-1-oxide
CAS No.:133659-38-8
Molecular Formula:C₁₃H₁₆ClNOS₂
Molecular Weight:301.861
Hs Code.:

Synonyms:(+/-)-trans-2-(4-chlorophenyl)-N-methyltetrahydrothiopyran-2-carbothioamide-1-oxide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-trans-2-(4-chlorophenyl)-N-methyltetrahydrothiopyran-2-carbothioamide-1-oxide

Chemical Property:

Purity/Quality:

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Technology Process of (+/-)-trans-2-(4-chlorophenyl)-N-methyltetrahydrothiopyran-2-carbothioamide-1-oxide

There total 7 articles about (+/-)-trans-2-(4-chlorophenyl)-N-methyltetrahydrothiopyran-2-carbothioamide-1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 124880-01-9,124880-02-0
(+/-)-2-(4-chlorophenyl)tetrahydrothiopyran-1-oxide

: 556-61-6
methyl thioisocyanate

: 133659-38-8
(+/-)-trans-2-(4-chlorophenyl)-N-methyltetrahydrothiopyran-2-carbothioamide-1-oxide

Guidance literature:: With n-butyllithium; In tetrahydrofuran; hexane; water; ethyl acetate;

Reference yield:

: 46124-27-0
S-(4-chlorobenzyl)isothiourea

: 124879-88-5,133659-38-8
(1R,2R)-2-(4-Chloro-phenyl)-1-oxo-hexahydro-1λ⁴-thiopyran-2-carbothioic acid methylamide

Guidance literature:: Multi-step reaction with 5 steps

1: 10 N aq. NaOH / 0.33 h / 70 °C

2: triethylbenzylammonium chloride, 10 N aq. NaOH / CH₂Cl₂ / Ambient temperature

3: m-chloroperoxybenzoic acid / CH₂Cl₂ / Ambient temperature

4: t-Bu₀K / tetrahydrofuran / Ambient temperature

5: 1.) n-BuLi, HMPA / 1.) THF, -75 deg C, 1 h, 2.) THF, RT, 18 h

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; n-butyllithium; potassium tert-butylate; N-benzyl-N,N,N-triethylammonium chloride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1021/jm00098a004

Reference yield:

: 104-83-6
1-Chloro-4-(chloromethyl)benzene

: 124879-88-5,133659-38-8
(1R,2R)-2-(4-Chloro-phenyl)-1-oxo-hexahydro-1λ⁴-thiopyran-2-carbothioic acid methylamide

Guidance literature:: Multi-step reaction with 6 steps

1: ethanol / 3 h / Heating

2: 10 N aq. NaOH / 0.33 h / 70 °C

3: triethylbenzylammonium chloride, 10 N aq. NaOH / CH₂Cl₂ / Ambient temperature

4: m-chloroperoxybenzoic acid / CH₂Cl₂ / Ambient temperature

5: t-Bu₀K / tetrahydrofuran / Ambient temperature

6: 1.) n-BuLi, HMPA / 1.) THF, -75 deg C, 1 h, 2.) THF, RT, 18 h

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; n-butyllithium; potassium tert-butylate; N-benzyl-N,N,N-triethylammonium chloride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1021/jm00098a004