[4-((E)-2-Carbamoyl-2-cyano-vinyl)-benzyl]-phosphonic acid di-tert-butyl ester

Base Information

Chemical Name:[4-((E)-2-Carbamoyl-2-cyano-vinyl)-benzyl]-phosphonic acid di-tert-butyl ester
CAS No.:132541-55-0
Molecular Formula:C₁₉H₂₇N₂O₄P
Molecular Weight:378.408
Hs Code.:

Synonyms:[4-((E)-2-Carbamoyl-2-cyano-vinyl)-benzyl]-phosphonic acid di-tert-butyl ester

Suppliers and Price of [4-((E)-2-Carbamoyl-2-cyano-vinyl)-benzyl]-phosphonic acid di-tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of [4-((E)-2-Carbamoyl-2-cyano-vinyl)-benzyl]-phosphonic acid di-tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of [4-((E)-2-Carbamoyl-2-cyano-vinyl)-benzyl]-phosphonic acid di-tert-butyl ester

There total 4 articles about [4-((E)-2-Carbamoyl-2-cyano-vinyl)-benzyl]-phosphonic acid di-tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 132541-47-0
bis(1,1-dimethylethyl) <(4-formylphenyl)methyl>phosphonate

: 107-91-5
cyanoacetic acid amide

: 132541-55-0
[4-((E)-2-Carbamoyl-2-cyano-vinyl)-benzyl]-phosphonic acid di-tert-butyl ester

Guidance literature:: With piperidine; In toluene; Ambient temperature;
DOI:10.1021/jm00109a008

Reference yield:

: 13086-84-5
di-tert-butyl phosphite

: 132541-55-0
[4-((E)-2-Carbamoyl-2-cyano-vinyl)-benzyl]-phosphonic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 83 percent / basic alumina oxide / Ambient temperature

2: 1.) NaH / 1.) DMF, RT, 15 min, 2.) 15 min

3: n-Bu₃SnH, azodiisobutyronitrile (AIBN) / toluene / 3 h / Heating

4: aq. HCl / CHCl₃ / 0.17 h

5: 77 percent / piperidine / toluene / Ambient temperature

With piperidine; hydrogenchloride; aluminum oxide; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium hydride; In chloroform; toluene;
DOI:10.1021/jm00109a008

Reference yield:

: 132541-45-8
bis(1,1-dimethylethyl) <<4-(diethoxymethyl)phenyl>hydroxymethyl>phosphonate

: 132541-55-0
[4-((E)-2-Carbamoyl-2-cyano-vinyl)-benzyl]-phosphonic acid di-tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 1.) NaH / 1.) DMF, RT, 15 min, 2.) 15 min

2: n-Bu₃SnH, azodiisobutyronitrile (AIBN) / toluene / 3 h / Heating

3: aq. HCl / CHCl₃ / 0.17 h

4: 77 percent / piperidine / toluene / Ambient temperature

With piperidine; hydrogenchloride; 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; sodium hydride; In chloroform; toluene;
DOI:10.1021/jm00109a008