2-(p-methoxybenzyl)-3-oxo-5-isoxazolidinemethanol trifluoromethanesulfonate

Base Information

Chemical Name:2-(p-methoxybenzyl)-3-oxo-5-isoxazolidinemethanol trifluoromethanesulfonate
CAS No.:104754-44-1
Molecular Formula:C₁₃H₁₄F₃NO₆S
Molecular Weight:369.318
Hs Code.:

Synonyms:2-(p-methoxybenzyl)-3-oxo-5-isoxazolidinemethanol trifluoromethanesulfonate

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Chemical Property of 2-(p-methoxybenzyl)-3-oxo-5-isoxazolidinemethanol trifluoromethanesulfonate

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Technology Process of 2-(p-methoxybenzyl)-3-oxo-5-isoxazolidinemethanol trifluoromethanesulfonate

There total 6 articles about 2-(p-methoxybenzyl)-3-oxo-5-isoxazolidinemethanol trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 104754-41-8
2-(p-methoxybenzyl)-3-oxo-5-isoxazolidinemethanol

: 104754-44-1
2-(p-methoxybenzyl)-3-oxo-5-isoxazolidinemethanol trifluoromethanesulfonate

Guidance literature:: With pyridine; In dichloromethane; at -78 - 20 ℃;
DOI:10.1016/S0040-4020(01)96774-2

Reference yield:

: 3717-21-3,3717-22-4,140461-28-5,140461-29-6,3235-04-9
p-methoxyl benzaldoxime

: 104754-44-1
2-(p-methoxybenzyl)-3-oxo-5-isoxazolidinemethanol trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1: 71 percent / sodium cyanoborohydride, 2N HCl / methanol / 2 h

2: 95 percent / Et₃N / tetrahydrofuran / 1 h / Ambient temperature

3: 97 percent / Ventron 50percent sodium hydride-oil dispersion / diethyl ether; dimethylformamide / Ambient temperature

4: 42 percent / H₂ / 10percent Pd-C / ethyl acetate / 1 h

5: 46 percent / 0.91M BF₃ / tetrahydrofuran / Ambient temperature

6: 85 percent / pyridine / CH₂Cl₂ / -78 - 20 °C

With pyridine; hydrogenchloride; Ventron 50percent sodium hydride-oil dispersion; boron trifluoride; hydrogen; sodium cyanoborohydride; triethylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)96774-2

Reference yield:

: 51307-59-6
N-(4-methoxybenzyl)hydroxylamine

: 104754-44-1
2-(p-methoxybenzyl)-3-oxo-5-isoxazolidinemethanol trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 5 steps

1: 95 percent / Et₃N / tetrahydrofuran / 1 h / Ambient temperature

2: 97 percent / Ventron 50percent sodium hydride-oil dispersion / diethyl ether; dimethylformamide / Ambient temperature

3: 42 percent / H₂ / 10percent Pd-C / ethyl acetate / 1 h

4: 46 percent / 0.91M BF₃ / tetrahydrofuran / Ambient temperature

5: 85 percent / pyridine / CH₂Cl₂ / -78 - 20 °C

With pyridine; Ventron 50percent sodium hydride-oil dispersion; boron trifluoride; hydrogen; triethylamine; palladium on activated charcoal; In tetrahydrofuran; diethyl ether; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(01)96774-2