4-methyl-N'-(1-(2-methylphenyl)ethylidene)benzenesulfonohydrazide

Base Information

• Chemical Name: 4-methyl-N'-(1-(2-methylphenyl)ethylidene)benzenesulfonohydrazide
• CAS No.: 67541-85-9
• Molecular Formula: C₁₆H₁₈N₂O₂S
• Molecular Weight: 302.397
• Mol file: 67541-85-9.mol

Synonyms:4-methyl-N'-(1-(2-methylphenyl)ethylidene)benzenesulfonohydrazide

Chemical Property of 4-methyl-N'-(1-(2-methylphenyl)ethylidene)benzenesulfonohydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-methyl-N'-(1-(2-methylphenyl)ethylidene)benzenesulfonohydrazide

There total 2 articles about 4-methyl-N'-(1-(2-methylphenyl)ethylidene)benzenesulfonohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

toluene-4-sulfonic acid hydrazide (1576-35-8) + 2-Methylacetophenone (577-16-2,122382-54-1) → 4-methyl-N'-(1-(2-methylphenyl)ethylidene)benzenesulfonohydrazide (67541-85-9)

Guidance literature:

In methanol; at 20 ℃;

DOI:10.1055/s-0037-1611003

Reference yield:

p-toluenesulfonyl chloride (98-59-9) → 4-methyl-N'-(1-(2-methylphenyl)ethylidene)benzenesulfonohydrazide (67541-85-9)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrazine / water; tetrahydrofuran / 0.5 h / 0 °C / Inert atmosphere

2: methanol / Inert atmosphere

With hydrazine; In tetrahydrofuran; methanol; water;

DOI:10.1002/ejoc.202000244

Reference yield: 89.0%

(1-(2,6-dimethylphenoxy)-4,4-diphenylbuta-2,3-dien-2-yl)-diphenylphosphine oxide + 4-methyl-N'-(1-(2-methylphenyl)ethylidene)benzenesulfonohydrazide (67541-85-9) → C37H31OP

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; sodium pivalate; potassium carbonate; In 1,4-dioxane; for 18h; Reflux;

DOI:10.1021/acscatal.6b02972

upstream raw materials:

toluene-4-sulfonic acid hydrazide

2-Methylacetophenone

p-toluenesulfonyl chloride

Downstream raw materials:

[(CH₃C₆H₄CCH₂)Co(N₄C₄₄H₂₈)]

1-methyl-2-(4-phenylbuta-2,3-dien-2-yl)benzene

2-(1-o-tolylethyl)benzo[d]oxazole

C₂₁H₂₁OP