2-[(1S,3R,3aR,3bS,6R,6aR,6bR)-3-(2-Methoxy-ethoxymethoxy)-3a,6-dimethyl-decahydro-cyclobutadicyclopenten-1-yl]-2-phenylselanyl-malonic acid dimethyl ester

Base Information

• Chemical Name: 2-[(1S,3R,3aR,3bS,6R,6aR,6bR)-3-(2-Methoxy-ethoxymethoxy)-3a,6-dimethyl-decahydro-cyclobutadicyclopenten-1-yl]-2-phenylselanyl-malonic acid dimethyl ester
• CAS No.: 132294-36-1
• Molecular Formula: C₂₇H₃₈O₇Se
• Molecular Weight: 553.555
• Mol file: 132294-36-1.mol

Synonyms:2-[(1S,3R,3aR,3bS,6R,6aR,6bR)-3-(2-Methoxy-ethoxymethoxy)-3a,6-dimethyl-decahydro-cyclobutadicyclopenten-1-yl]-2-phenylselanyl-malonic acid dimethyl ester

Chemical Property of 2-[(1S,3R,3aR,3bS,6R,6aR,6bR)-3-(2-Methoxy-ethoxymethoxy)-3a,6-dimethyl-decahydro-cyclobutadicyclopenten-1-yl]-2-phenylselanyl-malonic acid dimethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[(1S,3R,3aR,3bS,6R,6aR,6bR)-3-(2-Methoxy-ethoxymethoxy)-3a,6-dimethyl-decahydro-cyclobutadicyclopenten-1-yl]-2-phenylselanyl-malonic acid dimethyl ester

There total 27 articles about 2-[(1S,3R,3aR,3bS,6R,6aR,6bR)-3-(2-Methoxy-ethoxymethoxy)-3a,6-dimethyl-decahydro-cyclobutadicyclopenten-1-yl]-2-phenylselanyl-malonic acid dimethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

cyclopent-2-enone (930-30-3) → 2-[(1S,3R,3aR,3bS,6R,6aR,6bR)-3-(2-Methoxy-ethoxymethoxy)-3a,6-dimethyl-decahydro-cyclobutadicyclopenten-1-yl]-2-phenylselanyl-malonic acid dimethyl ester (132294-36-1)

Guidance literature:

Multi-step reaction with 6 steps

1: 51 percent / hexane / Irradiation

2: 2.) H₂O / 1.) THF; 2.) 20 deg C, 3 h

3: H₂ / Pt₂O

6: 1.) NaH / 1.) THF

With water; hydrogen; sodium hydride; Adam’s catalyst; In hexane;

DOI:10.1021/ja00319a052

Reference yield:

(1S,4S)-6-Methyl-2-trimethylsilanyloxy-bicyclo[2.2.1]hept-5-ene-2-carbonitrile → 2-[(1S,3R,3aR,3bS,6R,6aR,6bR)-3-(2-Methoxy-ethoxymethoxy)-3a,6-dimethyl-decahydro-cyclobutadicyclopenten-1-yl]-2-phenylselanyl-malonic acid dimethyl ester (132294-36-1)

Guidance literature:

Multi-step reaction with 6 steps

1: 51 percent / hexane / Irradiation

2: 2.) H₂O / 1.) THF; 2.) 20 deg C, 3 h

3: H₂ / Pt₂O

6: 1.) NaH / 1.) THF

With water; hydrogen; sodium hydride; Adam’s catalyst; In hexane;

DOI:10.1021/ja00319a052

Reference yield:

C14H18O (89165-83-3) → 2-[(1S,3R,3aR,3bS,6R,6aR,6bR)-3-(2-Methoxy-ethoxymethoxy)-3a,6-dimethyl-decahydro-cyclobutadicyclopenten-1-yl]-2-phenylselanyl-malonic acid dimethyl ester (132294-36-1)

Guidance literature:

Multi-step reaction with 4 steps

1: H₂ / Pt₂O

4: 1.) NaH / 1.) THF

With hydrogen; sodium hydride; Adam’s catalyst;

DOI:10.1021/ja00319a052

upstream raw materials:

Phenylselenyl bromide

2-[(1S,3R,3aR,3bS,6R,6aR,6bS)-3-(2-Methoxy-ethoxymethoxy)-3a,6-dimethyl-decahydro-cyclobutadicyclopenten-1-yl]-malonic acid dimethyl ester

cyclopent-2-enone

C₁₄H₁₈O