2(S)-2-(benzyloxycarbonylamino)-4-iodobutyric acid benzyl ester

Base Information

• Chemical Name: 2(S)-2-(benzyloxycarbonylamino)-4-iodobutyric acid benzyl ester
• CAS No.: 144876-97-1
• Molecular Formula: C₁₉H₂₀INO₄
• Molecular Weight: 453.277
• Mol file: 144876-97-1.mol

Synonyms:2(S)-2-(benzyloxycarbonylamino)-4-iodobutyric acid benzyl ester

Chemical Property of 2(S)-2-(benzyloxycarbonylamino)-4-iodobutyric acid benzyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2(S)-2-(benzyloxycarbonylamino)-4-iodobutyric acid benzyl ester

There total 5 articles about 2(S)-2-(benzyloxycarbonylamino)-4-iodobutyric acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

2(S)-2-(benzyloxycarbonylamino)-4-mesyloxybutyric acid benzyl ester → 2(S)-2-(benzyloxycarbonylamino)-4-iodobutyric acid benzyl ester (144876-97-1)

Guidance literature:

With sodium iodide; In acetone; for 5h; Heating;

DOI:10.1002/ardp.19953280414

Reference yield: 40.0%

Cbz-(L)-Glu-OBn (3705-42-8) → 2(S)-2-(benzyloxycarbonylamino)-4-iodobutyric acid benzyl ester (144876-97-1)

Guidance literature:

With [bis(acetoxy)iodo]benzene; iodine; In tetrachloromethane; for 3h; Heating; irradiation;

DOI:10.1021/jo9907742

Reference yield:

benzyl L-2-<(carbobenzxyloxy)amino>-4-hydroxybutyrate (58578-44-2) → 2(S)-2-(benzyloxycarbonylamino)-4-iodobutyric acid benzyl ester (144876-97-1)

Guidance literature:

With 1H-imidazole; iodine; triphenylphosphine; In tetrahydrofuran; at 0 ℃; for 2h;

upstream raw materials:

Cbz-(L)-Glu-OBn

N-benzyloxycarbonyl-5-O-benzyl-L-glutamic acid

Z-Asp-OBn

benzyl L-2-<(carbobenzxyloxy)amino>-4-hydroxybutyrate

Downstream raw materials:

phenylmethyl (S)-5-nitro-α-[[(phenylmethoxy)-carbonyl]amino]-2-pyridinebutanoate