[(R)-1-(2,4,6-Trimethyl-phenyl)-ethyl]-carbamic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Base Information

• Chemical Name: [(R)-1-(2,4,6-Trimethyl-phenyl)-ethyl]-carbamic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester
• CAS No.: 263351-61-7
• Molecular Formula: C₂₂H₃₅NO₂
• Molecular Weight: 345.525
• Mol file: 263351-61-7.mol

Synonyms:[(R)-1-(2,4,6-Trimethyl-phenyl)-ethyl]-carbamic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Chemical Property of [(R)-1-(2,4,6-Trimethyl-phenyl)-ethyl]-carbamic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [(R)-1-(2,4,6-Trimethyl-phenyl)-ethyl]-carbamic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester

There total 1 articles about [(R)-1-(2,4,6-Trimethyl-phenyl)-ethyl]-carbamic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

(1R,2S,5R)-menthyl chloroformate (14602-86-9,7635-53-2) + 1-mesitylethylamine (76808-14-5,20050-15-1) → [(R)-1-(2,4,6-Trimethyl-phenyl)-ethyl]-carbamic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester (263351-61-7) + [(S)-1-(2,4,6-Trimethyl-phenyl)-ethyl]-carbamic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester (263351-60-6)

Guidance literature:

In dichloromethane; at 20 ℃; for 40h;

DOI:10.1016/S0957-4166(99)00579-0

Reference yield: 79.0%

[(R)-1-(2,4,6-Trimethyl-phenyl)-ethyl]-carbamic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester (263351-61-7) → (R)-N-formyl-1-mesitylethylamine

Guidance literature:

With diisobutylaluminium hydride; In tetrahydrofuran; at 20 ℃; for 40h;

DOI:10.1016/S0957-4166(99)00579-0

Reference yield:

[(R)-1-(2,4,6-Trimethyl-phenyl)-ethyl]-carbamic acid (1R,2S,5R)-2-isopropyl-5-methyl-cyclohexyl ester (263351-61-7) → (R)-1-mesitylethylamine (20050-15-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 79 percent / DIBAL / tetrahydrofuran / 40 h / 20 °C

2: 100 percent / aq. HCl / methanol / 6 h / Heating

With hydrogenchloride; diisobutylaluminium hydride; In tetrahydrofuran; methanol; 1: Reduction / 2: Hydrolysis;

DOI:10.1016/S0957-4166(99)00579-0

upstream raw materials:

(1R,2S,5R)-menthyl chloroformate

1-mesitylethylamine

Downstream raw materials:

(R)-1-mesitylethylamine