methyl 2-((2S,3R,4R,4aS,6R,7R,8aS)-7-(tert-butyldimethylsilyloxy)-6-(2-(tert-butyldimethylsilyloxy)ethyl)-3-(4-methoxybenzyloxy)-4-methyloctahydropyrano[3,2-b]pyran-2-yl)acetate

Base Information

Chemical Name:methyl 2-((2S,3R,4R,4aS,6R,7R,8aS)-7-(tert-butyldimethylsilyloxy)-6-(2-(tert-butyldimethylsilyloxy)ethyl)-3-(4-methoxybenzyloxy)-4-methyloctahydropyrano[3,2-b]pyran-2-yl)acetate
CAS No.:157322-62-8
Molecular Formula:C₃₄H₆₀O₈Si₂
Molecular Weight:653.017
Hs Code.:

methyl 2-((2S,3R,4R,4aS,6R,7R,8aS)-7-(tert-butyldimethylsilyloxy)-6-(2-(tert-butyldimethylsilyloxy)ethyl)-3-(4-methoxybenzyloxy)-4-methyloctahydropyrano[3,2-b]pyran-2-yl)acetate

Synonyms:methyl 2-((2S,3R,4R,4aS,6R,7R,8aS)-7-(tert-butyldimethylsilyloxy)-6-(2-(tert-butyldimethylsilyloxy)ethyl)-3-(4-methoxybenzyloxy)-4-methyloctahydropyrano[3,2-b]pyran-2-yl)acetate

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Chemical Property of methyl 2-((2S,3R,4R,4aS,6R,7R,8aS)-7-(tert-butyldimethylsilyloxy)-6-(2-(tert-butyldimethylsilyloxy)ethyl)-3-(4-methoxybenzyloxy)-4-methyloctahydropyrano[3,2-b]pyran-2-yl)acetate

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Technology Process of methyl 2-((2S,3R,4R,4aS,6R,7R,8aS)-7-(tert-butyldimethylsilyloxy)-6-(2-(tert-butyldimethylsilyloxy)ethyl)-3-(4-methoxybenzyloxy)-4-methyloctahydropyrano[3,2-b]pyran-2-yl)acetate

There total 9 articles about methyl 2-((2S,3R,4R,4aS,6R,7R,8aS)-7-(tert-butyldimethylsilyloxy)-6-(2-(tert-butyldimethylsilyloxy)ethyl)-3-(4-methoxybenzyloxy)-4-methyloctahydropyrano[3,2-b]pyran-2-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 157322-61-7
[(2S,3R,4R,4aS,6R,7R,8aS)-7-Hydroxy-6-(2-hydroxy-ethyl)-3-(4-methoxy-benzyloxy)-4-methyl-octahydro-pyrano[3,2-b]pyran-2-yl]-acetic acid methyl ester

: 157322-62-8
methyl 2-((2S,3R,4R,4aS,6R,7R,8aS)-7-(tert-butyldimethylsilyloxy)-6-(2-(tert-butyldimethylsilyloxy)ethyl)-3-(4-methoxybenzyloxy)-4-methyloctahydropyrano[3,2-b]pyran-2-yl)acetate

Guidance literature:: With triethylamine; In dichloromethane; Ambient temperature;
DOI:10.1016/S0040-4039(00)91671-X

Reference yield:

: 142325-59-5
(S)-2-((2S,3S,5R,6R)-3,5-bis(tert-butyldimethylsilyloxy)-6-(2-(tert-butyldimethylsilyloxy)ethyl)tetrahydro-2H-pyran-2-yl)propanal

: 157322-62-8
methyl 2-((2S,3R,4R,4aS,6R,7R,8aS)-7-(tert-butyldimethylsilyloxy)-6-(2-(tert-butyldimethylsilyloxy)ethyl)-3-(4-methoxybenzyloxy)-4-methyloctahydropyrano[3,2-b]pyran-2-yl)acetate

Guidance literature:: Multi-step reaction with 8 steps

1: NiCl₂/CrCl₂ / tetrahydrofuran / Ambient temperature

3: BF₃*Et₂O / CH₂Cl₂ / 0 °C

4: HF*Py / acetonitrile / Ambient temperature

5: PPTS / CH₂Cl₂ / Ambient temperature

6: (n-Bu)4NF / tetrahydrofuran / Ambient temperature

7: PPTS / methanol / Ambient temperature

8: NEt₃ / CH₂Cl₂ / Ambient temperature

With chromium dichloride; boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; pyridine hydrogenfluoride; triethylamine; nickel dichloride; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1016/S0040-4039(00)91671-X

Reference yield:

: 89238-99-3
O-(4-methoxybenzyl)-trichloroacetimidate

: 157322-62-8
methyl 2-((2S,3R,4R,4aS,6R,7R,8aS)-7-(tert-butyldimethylsilyloxy)-6-(2-(tert-butyldimethylsilyloxy)ethyl)-3-(4-methoxybenzyloxy)-4-methyloctahydropyrano[3,2-b]pyran-2-yl)acetate

Guidance literature:: Multi-step reaction with 6 steps

1: BF₃*Et₂O / CH₂Cl₂ / 0 °C

2: HF*Py / acetonitrile / Ambient temperature

3: PPTS / CH₂Cl₂ / Ambient temperature

4: (n-Bu)4NF / tetrahydrofuran / Ambient temperature

5: PPTS / methanol / Ambient temperature

6: NEt₃ / CH₂Cl₂ / Ambient temperature

With boron trifluoride diethyl etherate; tetrabutyl ammonium fluoride; pyridinium p-toluenesulfonate; pyridine hydrogenfluoride; triethylamine; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1016/S0040-4039(00)91671-X