N-[2'-[[(1,1-Dimethylethyl)amino]sulfonyl][1,1'-biphenyl]-4-yl]-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Base Information

Chemical Name:N-[2'-[[(1,1-Dimethylethyl)amino]sulfonyl][1,1'-biphenyl]-4-yl]-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide
CAS No.:218631-49-3
Molecular Formula:C₂₈H₂₇F₃N₄O₄S
Molecular Weight:572.608
Hs Code.:
DSSTox Substance ID:DTXSID401102859

Synonyms:DTXSID401102859;218631-49-3;N-[2'-[[(1,1-Dimethylethyl)amino]sulfonyl][1,1'-biphenyl]-4-yl]-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Suppliers and Price of N-[2'-[[(1,1-Dimethylethyl)amino]sulfonyl][1,1'-biphenyl]-4-yl]-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of N-[2'-[[(1,1-Dimethylethyl)amino]sulfonyl][1,1'-biphenyl]-4-yl]-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

Chemical Property:

XLogP3:5.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:9
Rotatable Bond Count:8
Exact Mass:572.17051102
Heavy Atom Count:40
Complexity:952

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)NS(=O)(=O)C1=CC=CC=C1C2=CC=C(C=C2)NC(=O)C3=CC(=NN3C4=CC=C(C=C4)OC)C(F)(F)F

Technology Process of N-[2'-[[(1,1-Dimethylethyl)amino]sulfonyl][1,1'-biphenyl]-4-yl]-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide

There total 8 articles about N-[2'-[[(1,1-Dimethylethyl)amino]sulfonyl][1,1'-biphenyl]-4-yl]-1-(4-methoxyphenyl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 193006-34-7
4-(2'-tert-butylaminosulfonylphenyl)aniline

: 218632-09-8
2-(4-methoxy-phenyl)-5-trifluoromethyl-2H-pyrazole-3-carbonyl chloride

: 218631-49-3
1-(4-methoxyphenyl)-3-trifluoromethyl-1H-pyrazole-5-(N-(2'-N-tert-butylaminosulfonyl-[1,1']-biphen-4-yl))carboxamide

Guidance literature:: With pyridine; dmap; In dichloromethane; at 0 ℃;
DOI:10.1021/jm030212h

Reference yield:

: 367-57-7
1,1,1-Trifluoro-2,4-pentanedione

: 218631-49-3
1-(4-methoxyphenyl)-3-trifluoromethyl-1H-pyrazole-5-(N-(2'-N-tert-butylaminosulfonyl-[1,1']-biphen-4-yl))carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: 84 percent / AcOH / 2-methoxy-ethanol / 18 h / Heating

2: N-bromosuccinimide; benzoyl peroxide / CCl₄ / 18 h / Heating; irradiation

3: 18-crown-6 / acetonitrile / 18 h / 20 °C

4: 16.43 g / IR₄₀₀(OH^-) resin / methanol / 3 h / 20 °C

5: 3.03 g / sodium periodate; ruthenium(III) chloride / acetonitrile / 18 h / 20 °C

6: oxalyl chloride; DMF / CH₂Cl₂ / 4 h / 0 °C

7: pyridine; DMAP / CH₂Cl₂ / 0 °C

With pyridine; dmap; ruthenium trichloride; sodium periodate; N-Bromosuccinimide; oxalyl dichloride; 18-crown-6 ether; IR₄₀₀(OH^-) resin; acetic acid; N,N-dimethyl-formamide; dibenzoyl peroxide; In methanol; tetrachloromethane; dichloromethane; 2-methoxy-ethanol; acetonitrile;
DOI:10.1021/jm030212h

Reference yield:

: 19501-58-7
4-methoxyphenylhydrazine hydrochloride

: 218631-49-3
1-(4-methoxyphenyl)-3-trifluoromethyl-1H-pyrazole-5-(N-(2'-N-tert-butylaminosulfonyl-[1,1']-biphen-4-yl))carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1: 84 percent / AcOH / 2-methoxy-ethanol / 18 h / Heating

2: N-bromosuccinimide; benzoyl peroxide / CCl₄ / 18 h / Heating; irradiation

3: 18-crown-6 / acetonitrile / 18 h / 20 °C

4: 16.43 g / IR₄₀₀(OH^-) resin / methanol / 3 h / 20 °C

5: 3.03 g / sodium periodate; ruthenium(III) chloride / acetonitrile / 18 h / 20 °C

6: oxalyl chloride; DMF / CH₂Cl₂ / 4 h / 0 °C

7: pyridine; DMAP / CH₂Cl₂ / 0 °C

With pyridine; dmap; ruthenium trichloride; sodium periodate; N-Bromosuccinimide; oxalyl dichloride; 18-crown-6 ether; IR₄₀₀(OH^-) resin; acetic acid; N,N-dimethyl-formamide; dibenzoyl peroxide; In methanol; tetrachloromethane; dichloromethane; 2-methoxy-ethanol; acetonitrile;
DOI:10.1021/jm030212h