2(R,S)-{2-[(1H-indole-5-carbonyl)-amino]-benzoylamino}-3-phenyl-propionic aicd ethyl ester

Base Information

Chemical Name:2(R,S)-{2-[(1H-indole-5-carbonyl)-amino]-benzoylamino}-3-phenyl-propionic aicd ethyl ester
CAS No.:620167-33-1
Molecular Formula:C₂₇H₂₅N₃O₄
Molecular Weight:455.513
Hs Code.:

Synonyms:2(R,S)-{2-[(1H-indole-5-carbonyl)-amino]-benzoylamino}-3-phenyl-propionic aicd ethyl ester

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Chemical Property of 2(R,S)-{2-[(1H-indole-5-carbonyl)-amino]-benzoylamino}-3-phenyl-propionic aicd ethyl ester

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Technology Process of 2(R,S)-{2-[(1H-indole-5-carbonyl)-amino]-benzoylamino}-3-phenyl-propionic aicd ethyl ester

There total 3 articles about 2(R,S)-{2-[(1H-indole-5-carbonyl)-amino]-benzoylamino}-3-phenyl-propionic aicd ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 1670-81-1,142396-03-0
1H-Indole-5-carboxylic acid

: 32771-73-6
2(R,S)-(2-amino-benzoylamino)-3-phenyl-propionic acid ethyl ester

: 620167-33-1
2(R,S)-{2-[(1H-indole-5-carbonyl)-amino]-benzoylamino}-3-phenyl-propionic aicd ethyl ester

Guidance literature:: With 2-chloro-1-methyl-pyridinium iodide; triethylamine; In dichloromethane; for 12h; Heating;
DOI:10.1016/S0968-0896(02)00475-3

Reference yield:

: 118-48-9
isatoic anhydride

: 620167-33-1
2(R,S)-{2-[(1H-indole-5-carbonyl)-amino]-benzoylamino}-3-phenyl-propionic aicd ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / triethylamine / ethyl acetate / 2 h / Heating

2: 35 percent / 2-chloro-1-methylpyridinium iodide; Et₃N / CH₂Cl₂ / 12 h / Heating

With 2-chloro-1-methyl-pyridinium iodide; triethylamine; In dichloromethane; ethyl acetate;
DOI:10.1016/S0968-0896(02)00475-3

Reference yield:

: 3182-93-2
ethyl 2-amino-3-phenylpropanoate hydrochloride

: 620167-33-1
2(R,S)-{2-[(1H-indole-5-carbonyl)-amino]-benzoylamino}-3-phenyl-propionic aicd ethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / triethylamine / ethyl acetate / 2 h / Heating

2: 35 percent / 2-chloro-1-methylpyridinium iodide; Et₃N / CH₂Cl₂ / 12 h / Heating

With 2-chloro-1-methyl-pyridinium iodide; triethylamine; In dichloromethane; ethyl acetate;
DOI:10.1016/S0968-0896(02)00475-3