3-{5-[(5-Methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)-methyl]pyridine-2-yl}propanal

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Chemical Name:3-{5-[(5-Methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)-methyl]pyridine-2-yl}propanal
CAS No.:1226862-04-9
Molecular Formula:C₂₂H₁₈F₃N₅O₃
Molecular Weight:457.412
Hs Code.:

Synonyms:3-{5-[(5-Methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)-methyl]pyridine-2-yl}propanal

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Chemical Property of 3-{5-[(5-Methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)-methyl]pyridine-2-yl}propanal

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Technology Process of 3-{5-[(5-Methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)-methyl]pyridine-2-yl}propanal

There total 4 articles about 3-{5-[(5-Methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)-methyl]pyridine-2-yl}propanal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1226862-03-8
3-{5-[(5-Methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)-methyl]pyridin-2-yl}propan-1-ol

: 1226862-04-9
3-{5-[(5-Methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)-methyl]pyridine-2-yl}propanal

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 20 ℃; for 5h;

Reference yield:

: 1225380-66-4
2-Chloro-5-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)-methyl]pyridine

: 1226862-04-9
3-{5-[(5-Methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)-methyl]pyridine-2-yl}propanal

Guidance literature:: Multi-step reaction with 4 steps

1: trimethylsilyl bromide / propiononitrile / 2.17 h / 120 °C / Microwave irradiation

2: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

3: triethylamine; hydrogen / platinum(IV) oxide / ethanol; tetrahydrofuran / 4 h / 20 °C / 760.05 Torr

4: Dess-Martin periodane / dichloromethane / 5 h / 20 °C

With trimethylsilyl bromide; hydrogen; Dess-Martin periodane; triethylamine; platinum(IV) oxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane; propiononitrile;

Reference yield:

: 1225380-84-6
2-bromo-5-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)-methyl]pyridine

: 1226862-04-9
3-{5-[(5-Methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)-methyl]pyridine-2-yl}propanal

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere

2: triethylamine; hydrogen / platinum(IV) oxide / ethanol; tetrahydrofuran / 4 h / 20 °C / 760.05 Torr

3: Dess-Martin periodane / dichloromethane / 5 h / 20 °C

With hydrogen; Dess-Martin periodane; triethylamine; platinum(IV) oxide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; ethanol; dichloromethane;