4-amino-2-[5-fluoro-3-(2-fluorobenzyl)-1H-indazol-1-yl]-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

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Chemical Name:4-amino-2-[5-fluoro-3-(2-fluorobenzyl)-1H-indazol-1-yl]-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one
CAS No.:1228787-13-0
Molecular Formula:C₂₂H₁₈F₂N₆O
Molecular Weight:420.421
Hs Code.:

Synonyms:4-amino-2-[5-fluoro-3-(2-fluorobenzyl)-1H-indazol-1-yl]-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

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Chemical Property of 4-amino-2-[5-fluoro-3-(2-fluorobenzyl)-1H-indazol-1-yl]-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

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Technology Process of 4-amino-2-[5-fluoro-3-(2-fluorobenzyl)-1H-indazol-1-yl]-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

There total 5 articles about 4-amino-2-[5-fluoro-3-(2-fluorobenzyl)-1H-indazol-1-yl]-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1228788-10-0
methyl 3,3-dicyano-2,2-dimethylpropanoate

: 1426309-19-4
5-fluoro-3-(2-fluorobenzyl)-1H-indazole-1-carboximidamide

: 1228787-13-0
4-amino-2-[5-fluoro-3-(2-fluorobenzyl)-1H-indazol-1-yl]-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

Guidance literature:: With potassium tert-butylate; In tert-butyl alcohol; for 18h; Reflux;

Reference yield:

: 6942-39-8
methyl 2-bromo-5-fluorobenzoate

: 1228787-13-0
4-amino-2-[5-fluoro-3-(2-fluorobenzyl)-1H-indazol-1-yl]-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran / 0.83 h / -70 - 0 °C / Inert atmosphere

1.2: 1 h / Inert atmosphere

1.3: 20 °C / Inert atmosphere

2.1: boron trifluoride diethyl etherate / ethylene glycol / 5 h / 120 °C

3.1: copper(l) iodide / 1-methyl-pyrrolidin-2-one / 0.23 h / 170 °C

3.2: 0.25 h / Cooling with ice

4.1: potassium tert-butylate / tert-butyl alcohol / 18 h / Reflux

With copper(l) iodide; boron trifluoride diethyl etherate; potassium tert-butylate; sodium hexamethyldisilazane; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; ethylene glycol; tert-butyl alcohol;

Reference yield:

: 1179628-37-5
1-(2-bromo-5-fluorophenyl)-2-(2-fluorophenyl)ethanone

: 1228787-13-0
4-amino-2-[5-fluoro-3-(2-fluorobenzyl)-1H-indazol-1-yl]-5,5-dimethyl-5,7-dihydro-6H-pyrrolo[2,3-d]pyrimidin-6-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: boron trifluoride diethyl etherate / ethylene glycol / 5 h / 120 °C

2.1: copper(l) iodide / 1-methyl-pyrrolidin-2-one / 0.23 h / 170 °C

2.2: 0.25 h / Cooling with ice

3.1: potassium tert-butylate / tert-butyl alcohol / 18 h / Reflux

With copper(l) iodide; boron trifluoride diethyl etherate; potassium tert-butylate; In 1-methyl-pyrrolidin-2-one; ethylene glycol; tert-butyl alcohol;