dimethyl 2-[(4-[(trimethylsilyl)ethynyl]phenyl)ethynyl]spiro[9H-fluorene-9,5'(4'aH)-pyrrolo[1,2-b]pyridazine]-6',7'-dicarboxylate

Base Information

Chemical Name:dimethyl 2-[(4-[(trimethylsilyl)ethynyl]phenyl)ethynyl]spiro[9H-fluorene-9,5'(4'aH)-pyrrolo[1,2-b]pyridazine]-6',7'-dicarboxylate
CAS No.:1239233-51-2
Molecular Formula:C₃₆H₃₀N₂O₄Si
Molecular Weight:582.731
Hs Code.:

Synonyms:dimethyl 2-[(4-[(trimethylsilyl)ethynyl]phenyl)ethynyl]spiro[9H-fluorene-9,5'(4'aH)-pyrrolo[1,2-b]pyridazine]-6',7'-dicarboxylate

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Chemical Property of dimethyl 2-[(4-[(trimethylsilyl)ethynyl]phenyl)ethynyl]spiro[9H-fluorene-9,5'(4'aH)-pyrrolo[1,2-b]pyridazine]-6',7'-dicarboxylate

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Technology Process of dimethyl 2-[(4-[(trimethylsilyl)ethynyl]phenyl)ethynyl]spiro[9H-fluorene-9,5'(4'aH)-pyrrolo[1,2-b]pyridazine]-6',7'-dicarboxylate

There total 1 articles about dimethyl 2-[(4-[(trimethylsilyl)ethynyl]phenyl)ethynyl]spiro[9H-fluorene-9,5'(4'aH)-pyrrolo[1,2-b]pyridazine]-6',7'-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 58.0%

: 1210519-08-6
dimethyl 2-iodo-4a'H-spiro[fluorene-9,5'-pyrrolo[1,2-b]pyridazine]-6',7'-dicarboxylate

: 66228-76-0
4-(trimethylsilylethynyl)phenylacetylene

: 1239233-51-2
dimethyl 2-[(4-[(trimethylsilyl)ethynyl]phenyl)ethynyl]spiro[9H-fluorene-9,5'(4'aH)-pyrrolo[1,2-b]pyridazine]-6',7'-dicarboxylate

Guidance literature:: With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In tetrahydrofuran; at 50 ℃; for 5h; Inert atmosphere;
DOI:10.1007/s00706-010-0267-7

Reference yield: 57.0%

: 1239233-51-2
dimethyl 2-[(4-[(trimethylsilyl)ethynyl]phenyl)ethynyl]spiro[9H-fluorene-9,5'(4'aH)-pyrrolo[1,2-b]pyridazine]-6',7'-dicarboxylate

: 1239233-44-3
dimethyl 2-[(4-ethynylphenyl)ethynyl]spiro[9H-fluorene-9,5'(4'aH)-pyrrolo[1,2-b]pyridazine]-6',7'-dicarboxylate

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 4h; Inert atmosphere;
DOI:10.1007/s00706-010-0267-7

Reference yield:

: 1239233-51-2
dimethyl 2-[(4-[(trimethylsilyl)ethynyl]phenyl)ethynyl]spiro[9H-fluorene-9,5'(4'aH)-pyrrolo[1,2-b]pyridazine]-6',7'-dicarboxylate

: 1239233-58-9
C₃₃H₂₂N₂O₄

Guidance literature:: Multi-step reaction with 2 steps

1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

2: dichloromethane / 23 °C / Irradiation

With tetrabutyl ammonium fluoride; In tetrahydrofuran; dichloromethane;
DOI:10.1007/s00706-010-0267-7