C₄₅H₆₂O₉

Base Information

Chemical Name:C₄₅H₆₂O₉
CAS No.:161984-86-7
Molecular Formula:C₄₅H₆₂O₉
Molecular Weight:746.982
Hs Code.:

C<sub>45</sub>H<sub>62</sub>O<sub>9</sub>

Synonyms:C₄₅H₆₂O₉

Suppliers and Price of C₄₅H₆₂O₉

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₄₅H₆₂O₉

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Technology Process of C₄₅H₆₂O₉

There total 35 articles about C₄₅H₆₂O₉ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 161984-85-6
C₅₁H₇₆O₉Si

: 161984-86-7
C₄₅H₆₂O₉

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 25 ℃; for 3h;
DOI:10.1021/ja00108a051

Reference yield:

: 131311-17-6
[(2R,3S,4aR,6S,7R,8aS)-7-Benzyloxy-6-(2-benzyloxy-ethyl)-3-(tert-butyl-dimethyl-silanyloxy)-2,6,8a-trimethyl-octahydro-pyrano[3,2-b]pyran-2-yl]-methanol

: 161984-86-7
C₄₅H₆₂O₉

Guidance literature:: Multi-step reaction with 32 steps

1: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 2.) CH₂Cl₂, 0.5 h

2: 1.) NaHMDS / 1.) THF, 0 deg C, 10 min, 2.) 0.5 h

3: 100 percent / H₂, Na₂CO₃ / 10percent Pd/C / ethyl acetate / 12 h / 25 °C

4: 97 percent / CSA / CH₂Cl₂; methanol / 1 h / 0 °C

5: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 2.) CH₂Cl₂, 0.5 h

6: NaClO₂, NaH₂PO₄, 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O / 1 h / 25 °C

7: 91 percent / TBAF / tetrahydrofuran / 8 h / 65 °C

8: 1.) 2,4,6-trichlorobenzoyl chloride, Et₃N, 2.) DMAP / 1.) THF, 0 deg C, 2 h, 2.) THF, C₆H₆, 80 deg C, 1 h

9: 1.) LiHMDS, HMPA / 1.) THF, -78 deg C, 2 h, 2.) THF, -78 deg C to 25 deg C

10: 1.) t-BuLi, 2.) (2-thiophene)Cu(CN)Li, HMPA

11: 100 percent / PPTS / 1,2-dimethoxy-ethane; H₂O / 25 °C

12: 1.) BH₃*THF, 2.) 3 N NaOH, 30percent H₂O₂ / 1.) 0 deg C

13: 82 percent / LiOH / 1,2-dimethoxy-ethane; H₂O / 25 °C

14: 1.) 2,4,6-trichlorobenzoyl chloride, Et₃N, 2.) DMAP / 1.) THF, 0 deg C, 2 h, 2.) THF, C₆H₆, 80 deg C, 1 h

15: 1.) LiHMDS, HMPA / 1.) THF, -78 deg C, 2 h, 2.) THF, -78 deg C to 25 deg C

16: 66 percent / CrCl₂, NiCl₂ / dimethylformamide / 3 h / 25 °C / Irradiation

17: 89 percent / 1.) KH / diethyl ether / 25 °C

18: 67 percent / n-Bu₃SnH, AIBN / benzene / 80 °C

19: 1.) BH₃*THF, 2.) 3 N NaOH, 30percent H₂O₂ / 1.) -30 deg C

20: 96 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / -70 °C

21: 98 percent / DIBAL-H / CH₂Cl₂ / 0.08 h / -78 °C

22: 85 percent / Des-Martin periodinane / CH₂Cl₂ / 2 h / 25 °C

23: 1.) KHMDS, 18-crown-6 / 1.) THF, 0 deg C, 0.5 h, 2.) THF, 3 h

24: 100 percent / CSA / CH₂Cl₂; methanol / 1 h / 25 °C

25: 90 percent / KH / tetrahydrofuran / 2 h / 25 °C

26: 1.) DIBAL-H, 2.) MeOH / 1.) CH₂Cl₂, -78 deg C, 2 min

27: 98 percent / CH₂Cl₂ / 12 h / 25 °C

28: 96 percent / DIBAL-H / CH₂Cl₂ / 2 h / -78 °C

29: 99 percent / Ti(OiPr)4, (+)-diethyl tartrate, 5 N t-BuOOH / CH₂Cl₂; decane / 5 h / -20 °C

30: SO₃*pyridine, Et₃N / CH₂Cl₂; dimethylsulfoxide / 0 °C

31: NaHMDS / tetrahydrofuran / 1 h / 25 °C

32: 100 percent / TBAF / tetrahydrofuran / 3 h / 25 °C

With 2,6-dimethylpyridine; chromium dichloride; titanium(IV) isopropylate; methanol; tert.-butylhydroperoxide; N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; lithium hydroxide; sodium hydroxide; sodium chlorite; sodium dihydrogenphosphate; borane-THF; 2-methyl-but-2-ene; oxalyl dichloride; 18-crown-6 ether; pyridine-SO₃ complex; 2,2'-azobis(isobutyronitrile); 2,4,6-trichlorobenzoyl chloride; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; hydrogen; dihydrogen peroxide; tert.-butyl lithium; tri-n-butyl-tin hydride; sodium hexamethyldisilazane; pyridinium p-toluenesulfonate; potassium hydride; potassium hexamethylsilazane; diisobutylaluminium hydride; sodium carbonate; Dess-Martin periodane; dimethyl sulfoxide; thien-2-yl(cyano)copper lithium; (+)-Weinsaeure-diethylester; triethylamine; nickel dichloride; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; diethyl ether; decane; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol; benzene;
DOI:10.1021/ja00108a051

Reference yield:

: 131311-18-7
(2S,3S,4aR,6S,7R,8aS)-7-Benzyloxy-6-(2-benzyloxy-ethyl)-3-(tert-butyl-dimethyl-silanyloxy)-2,6,8a-trimethyl-octahydro-pyrano[3,2-b]pyran-2-carbaldehyde

: 161984-86-7
C₄₅H₆₂O₉

Guidance literature:: Multi-step reaction with 31 steps

1: 1.) NaHMDS / 1.) THF, 0 deg C, 10 min, 2.) 0.5 h

2: 100 percent / H₂, Na₂CO₃ / 10percent Pd/C / ethyl acetate / 12 h / 25 °C

3: 97 percent / CSA / CH₂Cl₂; methanol / 1 h / 0 °C

4: 1.) (COCl)2, DMSO, 2.) Et₃N / 1.) CH₂Cl₂, -78 deg C, 2.) CH₂Cl₂, 0.5 h

5: NaClO₂, NaH₂PO₄, 2-methyl-2-butene / 2-methyl-propan-2-ol; H₂O / 1 h / 25 °C

6: 91 percent / TBAF / tetrahydrofuran / 8 h / 65 °C

7: 1.) 2,4,6-trichlorobenzoyl chloride, Et₃N, 2.) DMAP / 1.) THF, 0 deg C, 2 h, 2.) THF, C₆H₆, 80 deg C, 1 h

8: 1.) LiHMDS, HMPA / 1.) THF, -78 deg C, 2 h, 2.) THF, -78 deg C to 25 deg C

9: 1.) t-BuLi, 2.) (2-thiophene)Cu(CN)Li, HMPA

10: 100 percent / PPTS / 1,2-dimethoxy-ethane; H₂O / 25 °C

11: 1.) BH₃*THF, 2.) 3 N NaOH, 30percent H₂O₂ / 1.) 0 deg C

12: 82 percent / LiOH / 1,2-dimethoxy-ethane; H₂O / 25 °C

13: 1.) 2,4,6-trichlorobenzoyl chloride, Et₃N, 2.) DMAP / 1.) THF, 0 deg C, 2 h, 2.) THF, C₆H₆, 80 deg C, 1 h

14: 1.) LiHMDS, HMPA / 1.) THF, -78 deg C, 2 h, 2.) THF, -78 deg C to 25 deg C

15: 66 percent / CrCl₂, NiCl₂ / dimethylformamide / 3 h / 25 °C / Irradiation

16: 89 percent / 1.) KH / diethyl ether / 25 °C

17: 67 percent / n-Bu₃SnH, AIBN / benzene / 80 °C

18: 1.) BH₃*THF, 2.) 3 N NaOH, 30percent H₂O₂ / 1.) -30 deg C

19: 96 percent / 2,6-lutidine / CH₂Cl₂ / 1 h / -70 °C

20: 98 percent / DIBAL-H / CH₂Cl₂ / 0.08 h / -78 °C

21: 85 percent / Des-Martin periodinane / CH₂Cl₂ / 2 h / 25 °C

22: 1.) KHMDS, 18-crown-6 / 1.) THF, 0 deg C, 0.5 h, 2.) THF, 3 h

23: 100 percent / CSA / CH₂Cl₂; methanol / 1 h / 25 °C

24: 90 percent / KH / tetrahydrofuran / 2 h / 25 °C

25: 1.) DIBAL-H, 2.) MeOH / 1.) CH₂Cl₂, -78 deg C, 2 min

26: 98 percent / CH₂Cl₂ / 12 h / 25 °C

27: 96 percent / DIBAL-H / CH₂Cl₂ / 2 h / -78 °C

28: 99 percent / Ti(OiPr)4, (+)-diethyl tartrate, 5 N t-BuOOH / CH₂Cl₂; decane / 5 h / -20 °C

29: SO₃*pyridine, Et₃N / CH₂Cl₂; dimethylsulfoxide / 0 °C

30: NaHMDS / tetrahydrofuran / 1 h / 25 °C

31: 100 percent / TBAF / tetrahydrofuran / 3 h / 25 °C

With 2,6-dimethylpyridine; chromium dichloride; titanium(IV) isopropylate; methanol; tert.-butylhydroperoxide; N,N,N,N,N,N-hexamethylphosphoric triamide; dmap; lithium hydroxide; sodium hydroxide; sodium chlorite; sodium dihydrogenphosphate; borane-THF; 2-methyl-but-2-ene; oxalyl dichloride; 18-crown-6 ether; pyridine-SO₃ complex; 2,2'-azobis(isobutyronitrile); 2,4,6-trichlorobenzoyl chloride; camphor-10-sulfonic acid; tetrabutyl ammonium fluoride; hydrogen; dihydrogen peroxide; tert.-butyl lithium; tri-n-butyl-tin hydride; sodium hexamethyldisilazane; pyridinium p-toluenesulfonate; potassium hydride; potassium hexamethylsilazane; diisobutylaluminium hydride; sodium carbonate; Dess-Martin periodane; dimethyl sulfoxide; thien-2-yl(cyano)copper lithium; (+)-Weinsaeure-diethylester; triethylamine; nickel dichloride; lithium hexamethyldisilazane; palladium on activated charcoal; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; diethyl ether; decane; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; tert-butyl alcohol; benzene;
DOI:10.1021/ja00108a051