(R)-4-benzyl-3-((R)-2-tert-butoxy-2-(4-(4-chlorophenyl)-1,2,3,6-tetramethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetyl)oxazolidin-2-one

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Chemical Name:(R)-4-benzyl-3-((R)-2-tert-butoxy-2-(4-(4-chlorophenyl)-1,2,3,6-tetramethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetyl)oxazolidin-2-one
CAS No.:1436855-95-6
Molecular Formula:C₃₃H₃₆ClN₃O₄
Molecular Weight:574.12
Hs Code.:

Synonyms:(R)-4-benzyl-3-((R)-2-tert-butoxy-2-(4-(4-chlorophenyl)-1,2,3,6-tetramethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetyl)oxazolidin-2-one

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Chemical Property of (R)-4-benzyl-3-((R)-2-tert-butoxy-2-(4-(4-chlorophenyl)-1,2,3,6-tetramethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetyl)oxazolidin-2-one

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Technology Process of (R)-4-benzyl-3-((R)-2-tert-butoxy-2-(4-(4-chlorophenyl)-1,2,3,6-tetramethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetyl)oxazolidin-2-one

There total 16 articles about (R)-4-benzyl-3-((R)-2-tert-butoxy-2-(4-(4-chlorophenyl)-1,2,3,6-tetramethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetyl)oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 1436854-71-5
2-tert-butoxy-2-(4-(4-chlorophenyl)-1,2,3,6-tetramethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid

: 40217-17-2,90719-32-7,120574-96-1,102029-44-7
(R)-4-(phenylmethyl)-2-oxazolidinone

: 1436855-94-5
(R)-4-benzyl-3-((S)-2-tert-butoxy-2-(4-(4-chlorophenyl)-1,2,3,6-tetramethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetyl)oxazolidin-2-one

: 1436855-95-6
(R)-4-benzyl-3-((R)-2-tert-butoxy-2-(4-(4-chlorophenyl)-1,2,3,6-tetramethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetyl)oxazolidin-2-one

Guidance literature:: 2-tert-butoxy-2-(4-(4-chlorophenyl)-1,2,3,6-tetramethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetic acid; With O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 35 ℃; for 5h;

(R)-4-(phenylmethyl)-2-oxazolidinone; With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 0.5h;

Reference yield:

: 1436855-51-4
(4-(4-chlorophenyl)-1-(4-methoxybenzyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)methanol

: 1436855-94-5
(R)-4-benzyl-3-((S)-2-tert-butoxy-2-(4-(4-chlorophenyl)-1,2,3,6-tetramethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetyl)oxazolidin-2-one

: 1436855-95-6
(R)-4-benzyl-3-((R)-2-tert-butoxy-2-(4-(4-chlorophenyl)-1,2,3,6-tetramethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 8 steps

1.1: sulfur trioxide pyridine complex; triethylamine / dimethyl sulfoxide / 3 h / 10 - 25 °C

2.1: zinc(II) iodide / dichloromethane / 4 h / 0 - 25 °C / Inert atmosphere

3.1: hydrogenchloride / water / 18 h / 100 °C

4.1: sulfuric acid / 18 h / Reflux

5.1: perchloric acid / dichloromethane; ethyl acetate / 4 h / 0 - 20 °C

6.1: tetrabutylammomium bromide; potassium hydroxide / dichloromethane / 10 h / 20 - 25 °C

7.1: sodium hydroxide; methanol / tetrahydrofuran / 18 h / 25 °C

8.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / tetrahydrofuran / 5 h / 35 °C

8.2: 0.5 h / 20 °C

With hydrogenchloride; methanol; perchloric acid; sulfuric acid; tetrabutylammomium bromide; sulfur trioxide pyridine complex; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; triethylamine; N-ethyl-N,N-diisopropylamine; potassium hydroxide; sodium hydroxide; zinc(II) iodide; In tetrahydrofuran; dichloromethane; water; dimethyl sulfoxide; ethyl acetate;

Reference yield:

: 1436855-52-5
4-(4-chlorophenyl)-1-(4-methoxybenzyl)-2,3,6-trimethyl-1H-pyrrolo[2,3-b]pyridine-5-carboaldehyde

: 1436855-94-5
(R)-4-benzyl-3-((S)-2-tert-butoxy-2-(4-(4-chlorophenyl)-1,2,3,6-tetramethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetyl)oxazolidin-2-one

: 1436855-95-6
(R)-4-benzyl-3-((R)-2-tert-butoxy-2-(4-(4-chlorophenyl)-1,2,3,6-tetramethyl-1H-pyrrolo[2,3-b]pyridin-5-yl)acetyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: zinc(II) iodide / dichloromethane / 4 h / 0 - 25 °C / Inert atmosphere

2.1: hydrogenchloride / water / 18 h / 100 °C

3.1: sulfuric acid / 18 h / Reflux

4.1: perchloric acid / dichloromethane; ethyl acetate / 4 h / 0 - 20 °C

5.1: tetrabutylammomium bromide; potassium hydroxide / dichloromethane / 10 h / 20 - 25 °C

6.1: sodium hydroxide; methanol / tetrahydrofuran / 18 h / 25 °C

7.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / tetrahydrofuran / 5 h / 35 °C

7.2: 0.5 h / 20 °C

With hydrogenchloride; methanol; perchloric acid; sulfuric acid; tetrabutylammomium bromide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; N-ethyl-N,N-diisopropylamine; potassium hydroxide; sodium hydroxide; zinc(II) iodide; In tetrahydrofuran; dichloromethane; water; ethyl acetate;