C₂₇H₂₃F₃N₆O₅S₂

Base Information

Chemical Name:C₂₇H₂₃F₃N₆O₅S₂
CAS No.:1164203-03-5
Molecular Formula:C₂₇H₂₃F₃N₆O₅S₂
Molecular Weight:632.644
Hs Code.:

C<sub>27</sub>H<sub>23</sub>F<sub>3</sub>N<sub>6</sub>O<sub>5</sub>S<sub>2</sub>

Synonyms:C₂₇H₂₃F₃N₆O₅S₂

Suppliers and Price of C₂₇H₂₃F₃N₆O₅S₂

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of C₂₇H₂₃F₃N₆O₅S₂

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of C₂₇H₂₃F₃N₆O₅S₂

There total 8 articles about C₂₇H₂₃F₃N₆O₅S₂ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1005627-55-3
1-ethyl-3-methylpyrazole-4-sulfonyl chloride

: 1161921-55-6
(4S)-4-[4-cyano-2-(methylsulfonyl)phenyl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carbonitrile

: 1164203-03-5
C₂₇H₂₃F₃N₆O₅S₂

Guidance literature:: (4S)-4-[4-cyano-2-(methylsulfonyl)phenyl]-6-methyl-2-oxo-1-[3-(trifluoromethyl)phenyl]-1,2,3,4-tetrahydropyrimidine-5-carbonitrile; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 0.333333h; Inert atmosphere;

1-ethyl-3-methylpyrazole-4-sulfonyl chloride; In tetrahydrofuran; at 20 ℃; for 0.5h;

Reference yield:

: 170572-49-3
2-fluoro-4-cyanotoluene

: 1164203-03-5
C₂₇H₂₃F₃N₆O₅S₂

Guidance literature:: Multi-step reaction with 8 steps

1.1: N,N-dimethyl-formamide dimethyl acetal / N,N-dimethyl-formamide / Inert atmosphere; Reflux

1.2: 1 h / 20 °C

2.1: dimethyl sulfoxide / Cooling with ice

3.1: phosphorus pentoxide; triethyl phosphate / tert-butyl methyl ether / 50 °C / Inert atmosphere; Reflux

4.1: chiral silica gel phase based on the selector poly(N-methacryloyl-D-leucinedicyclopropylmethylamide) / ethyl acetate; isopropyl alcohol; tetrahydrofuran; 2-Methylpentane / 24 °C / Resolution of racemate

5.1: morpholine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 1.5 h / 20 °C / Inert atmosphere

6.1: HATU / N,N-dimethyl-formamide / 0.33 h / 0 °C / Inert atmosphere

6.2: 4 h / 20 °C

7.1: Burgess Reagent / tetrahydrofuran / 1.5 h / 20 °C / Inert atmosphere

8.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 - 20 °C / Inert atmosphere

8.2: 0.5 h / 20 °C

With morpholine; Burgess Reagent; triethyl phosphate; phosphorus pentoxide; sodium hydride; N,N-dimethyl-formamide dimethyl acetal; HATU; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 2-Methylpentane; tert-butyl methyl ether; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

: 105942-10-7
3-fluoro-4-formylbenzonitrile

: 1164203-03-5
C₂₇H₂₃F₃N₆O₅S₂

Guidance literature:: Multi-step reaction with 7 steps

1.1: dimethyl sulfoxide / Cooling with ice

2.1: phosphorus pentoxide; triethyl phosphate / tert-butyl methyl ether / 50 °C / Inert atmosphere; Reflux

3.1: chiral silica gel phase based on the selector poly(N-methacryloyl-D-leucinedicyclopropylmethylamide) / ethyl acetate; isopropyl alcohol; tetrahydrofuran; 2-Methylpentane / 24 °C / Resolution of racemate

4.1: morpholine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 1.5 h / 20 °C / Inert atmosphere

5.1: HATU / N,N-dimethyl-formamide / 0.33 h / 0 °C / Inert atmosphere

5.2: 4 h / 20 °C

6.1: Burgess Reagent / tetrahydrofuran / 1.5 h / 20 °C / Inert atmosphere

7.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 - 20 °C / Inert atmosphere

7.2: 0.5 h / 20 °C

With morpholine; Burgess Reagent; triethyl phosphate; phosphorus pentoxide; sodium hydride; HATU; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 2-Methylpentane; tert-butyl methyl ether; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide; isopropyl alcohol;