3-[7-trifluoromethyl-5-(2-trifluoromethylphenyl)-1H-benzimidazol-2-yl]-1,8-dioxa-2-azaspiro[4.5]dec-2-ene

Base Information

Chemical Name:3-[7-trifluoromethyl-5-(2-trifluoromethylphenyl)-1H-benzimidazol-2-yl]-1,8-dioxa-2-azaspiro[4.5]dec-2-ene
CAS No.:1221349-68-3
Molecular Formula:C₂₂H₁₇F₆N₃O₂
Molecular Weight:469.386
Hs Code.:

Synonyms:3-[7-trifluoromethyl-5-(2-trifluoromethylphenyl)-1H-benzimidazol-2-yl]-1,8-dioxa-2-azaspiro[4.5]dec-2-ene

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Chemical Property of 3-[7-trifluoromethyl-5-(2-trifluoromethylphenyl)-1H-benzimidazol-2-yl]-1,8-dioxa-2-azaspiro[4.5]dec-2-ene

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Technology Process of 3-[7-trifluoromethyl-5-(2-trifluoromethylphenyl)-1H-benzimidazol-2-yl]-1,8-dioxa-2-azaspiro[4.5]dec-2-ene

There total 8 articles about 3-[7-trifluoromethyl-5-(2-trifluoromethylphenyl)-1H-benzimidazol-2-yl]-1,8-dioxa-2-azaspiro[4.5]dec-2-ene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1276127-39-9
C₂₂H₁₇F₆N₃O₅

: 1221349-68-3
3-[7-trifluoromethyl-5-(2-trifluoromethylphenyl)-1H-benzimidazol-2-yl]-1,8-dioxa-2-azaspiro[4.5]dec-2-ene

Guidance literature:: With iron; acetic acid; In methanol; at 100 ℃; for 4h;
DOI:10.1021/jm101075v

Reference yield:

: 29943-42-8,143562-54-3
Tetrahydro-4H-pyran-4-one

: 1221349-68-3
3-[7-trifluoromethyl-5-(2-trifluoromethylphenyl)-1H-benzimidazol-2-yl]-1,8-dioxa-2-azaspiro[4.5]dec-2-ene

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium amide / diethyl ether / 1 h / 20 °C

1.2: 16 h / 20 °C

1.3: 67 h / 20 °C

2.1: lithium hydrochloride monohydrate; water / methanol / 16 h / 20 °C

3.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 1 h / 20 °C

4.1: sodium hydride / tetrahydrofuran; mineral oil / 0 °C

4.2: 16.5 h / 0 - 20 °C

5.1: iron; acetic acid / methanol / 4 h / 100 °C

With oxalyl dichloride; lithium hydrochloride monohydrate; water; iron; sodium hydride; sodium amide; acetic acid; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; diethyl ether; dichloromethane; mineral oil;
DOI:10.1021/jm101075v

Reference yield:

: 1221349-85-4
3-nitro-2',5-bis(trifluoromethyl)-[1,1'-biphenyl]-4-amine

: 1221349-68-3
3-[7-trifluoromethyl-5-(2-trifluoromethylphenyl)-1H-benzimidazol-2-yl]-1,8-dioxa-2-azaspiro[4.5]dec-2-ene

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran; mineral oil / 0 °C

1.2: 16.5 h / 0 - 20 °C

2.1: iron; acetic acid / methanol / 4 h / 100 °C

With iron; sodium hydride; acetic acid; In tetrahydrofuran; methanol; mineral oil;
DOI:10.1021/jm101075v