Thiocarbonic acid O-benzyl ester S-[(R)-2-((R)-2-hydroxy-2,3,4,9-tetrahydro-1H-β-carbolin-1-yl)-2-(2,2,2-trichloro-ethoxycarbonylamino)-ethyl] ester

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Chemical Name:Thiocarbonic acid O-benzyl ester S-[(R)-2-((R)-2-hydroxy-2,3,4,9-tetrahydro-1H-β-carbolin-1-yl)-2-(2,2,2-trichloro-ethoxycarbonylamino)-ethyl] ester
CAS No.:120296-17-5
Molecular Formula:C₂₄H₂₄Cl₃N₃O₅S
Molecular Weight:572.897
Hs Code.:

Synonyms:Thiocarbonic acid O-benzyl ester S-[(R)-2-((R)-2-hydroxy-2,3,4,9-tetrahydro-1H-β-carbolin-1-yl)-2-(2,2,2-trichloro-ethoxycarbonylamino)-ethyl] ester

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Chemical Property of Thiocarbonic acid O-benzyl ester S-[(R)-2-((R)-2-hydroxy-2,3,4,9-tetrahydro-1H-β-carbolin-1-yl)-2-(2,2,2-trichloro-ethoxycarbonylamino)-ethyl] ester

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Technology Process of Thiocarbonic acid O-benzyl ester S-[(R)-2-((R)-2-hydroxy-2,3,4,9-tetrahydro-1H-β-carbolin-1-yl)-2-(2,2,2-trichloro-ethoxycarbonylamino)-ethyl] ester

There total 6 articles about Thiocarbonic acid O-benzyl ester S-[(R)-2-((R)-2-hydroxy-2,3,4,9-tetrahydro-1H-β-carbolin-1-yl)-2-(2,2,2-trichloro-ethoxycarbonylamino)-ethyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 23.0%

: 120296-06-2,137036-42-1
C₂₄H₂₄Cl₃N₃O₅S

: 136949-78-5
C₂₄H₂₄Cl₃N₃O₅S

: 120296-17-5,120296-18-6
Thiocarbonic acid O-benzyl ester S-[(S)-2-((R)-2-hydroxy-2,3,4,9-tetrahydro-1H-β-carbolin-1-yl)-2-(2,2,2-trichloro-ethoxycarbonylamino)-ethyl] ester

: 120296-17-5,120296-18-6
Thiocarbonic acid O-benzyl ester S-[(S)-2-((S)-2-hydroxy-2,3,4,9-tetrahydro-1H-β-carbolin-1-yl)-2-(2,2,2-trichloro-ethoxycarbonylamino)-ethyl] ester

Guidance literature:: With toluene-4-sulfonic acid; In dichloromethane; for 1h; Yields of byproduct given; Ambient temperature;
DOI:10.1248/cpb.39.1672

Reference yield: 23.0%

: 120296-06-2,137036-42-1
C₂₄H₂₄Cl₃N₃O₅S

: 136949-78-5
C₂₄H₂₄Cl₃N₃O₅S

: 120296-17-5,120296-18-6
Thiocarbonic acid O-benzyl ester S-[(S)-2-((R)-2-hydroxy-2,3,4,9-tetrahydro-1H-β-carbolin-1-yl)-2-(2,2,2-trichloro-ethoxycarbonylamino)-ethyl] ester

: 120296-17-5,120296-18-6
Thiocarbonic acid O-benzyl ester S-[(S)-2-((S)-2-hydroxy-2,3,4,9-tetrahydro-1H-β-carbolin-1-yl)-2-(2,2,2-trichloro-ethoxycarbonylamino)-ethyl] ester

Guidance literature:: With toluene-4-sulfonic acid; In dichloromethane; for 1h; Yields of byproduct given; Ambient temperature;
DOI:10.1248/cpb.39.1672

Reference yield:

: 4761-34-6
N-Hydroxytryptamine

: 120296-17-5
Thiocarbonic acid O-benzyl ester S-[(R)-2-((R)-2-hydroxy-2,3,4,9-tetrahydro-1H-β-carbolin-1-yl)-2-(2,2,2-trichloro-ethoxycarbonylamino)-ethyl] ester

Guidance literature:: Multi-step reaction with 2 steps

1: 77.6 percent / CH₂Cl₂ / 2 h / Ambient temperature

2: trifluoroacetic acid / CH₂Cl₂ / 2 h / -78 °C

With trifluoroacetic acid; In dichloromethane;
DOI:10.1021/ja00189a060