[4-benzo[1,3]dioxol-5-yl-6-[(4-fluorophenyl)hydroxymethyl]benzothiazol-2-yl]carbamic acid tert-butylester

Base Information

• Chemical Name: [4-benzo[1,3]dioxol-5-yl-6-[(4-fluorophenyl)hydroxymethyl]benzothiazol-2-yl]carbamic acid tert-butylester
• CAS No.: 1155287-23-2
• Molecular Formula: C₂₆H₂₃FN₂O₅S
• Molecular Weight: 494.543

Synonyms:[4-benzo[1,3]dioxol-5-yl-6-[(4-fluorophenyl)hydroxymethyl]benzothiazol-2-yl]carbamic acid tert-butylester

Chemical Property of [4-benzo[1,3]dioxol-5-yl-6-[(4-fluorophenyl)hydroxymethyl]benzothiazol-2-yl]carbamic acid tert-butylester

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Technology Process of [4-benzo[1,3]dioxol-5-yl-6-[(4-fluorophenyl)hydroxymethyl]benzothiazol-2-yl]carbamic acid tert-butylester

There total 1 articles about [4-benzo[1,3]dioxol-5-yl-6-[(4-fluorophenyl)hydroxymethyl]benzothiazol-2-yl]carbamic acid tert-butylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

{4-bromo-6-[(4-fluoro-phenyl)-hydroxy-methyl]-benzothiazol-2-yl}-carbamic Acid tert-butyl Ester (1155287-21-0) + 3,4-(methylenedioxy)-benzeneboronic acid (94839-07-3) → [4-benzo[1,3]dioxol-5-yl-6-[(4-fluorophenyl)hydroxymethyl]benzothiazol-2-yl]carbamic acid tert-butylester (1155287-23-2)

Guidance literature:

With sodium carbonate; palladium diacetate; triphenylphosphine; In 1,4-dioxane; water; Heating / reflux;

Reference yield: 41.0%

[4-benzo[1,3]dioxol-5-yl-6-[(4-fluorophenyl)hydroxymethyl]benzothiazol-2-yl]carbamic acid tert-butylester (1155287-23-2) → 4-Benzo[1,3]dioxol-5-yl-6-(4-fluoro-benzyl)-benzothiazol-2-ylamine (1155286-20-6)

Guidance literature:

With triethylsilane; trifluoroacetic acid; at 20 ℃;

Reference yield: 34.0%

[4-benzo[1,3]dioxol-5-yl-6-[(4-fluorophenyl)hydroxymethyl]benzothiazol-2-yl]carbamic acid tert-butylester (1155287-23-2) → (2-Amino-4-benzo[1,3]dioxol-5-yl-benzothiazol-6-yl)-(4-fluoro-phenyl)-methanol (1155286-21-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃;

upstream raw materials:

{4-bromo-6-[(4-fluoro-phenyl)-hydroxy-methyl]-benzothiazol-2-yl}-carbamic Acid tert-butyl Ester

3,4-(methylenedioxy)-benzeneboronic acid

Downstream raw materials:

4-Benzo[1,3]dioxol-5-yl-6-(4-fluoro-benzyl)-benzothiazol-2-ylamine

(2-Amino-4-benzo[1,3]dioxol-5-yl-benzothiazol-6-yl)-(4-fluoro-phenyl)-methanol

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