2-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-4-(methoxymethoxy)benzonitrile

Base Information

Chemical Name:2-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-4-(methoxymethoxy)benzonitrile
CAS No.:1333263-46-9
Molecular Formula:C₂₀H₁₉F₂N₃O₄S
Molecular Weight:435.451
Hs Code.:

Synonyms:2-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-4-(methoxymethoxy)benzonitrile

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Chemical Property of 2-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-4-(methoxymethoxy)benzonitrile

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Technology Process of 2-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-4-(methoxymethoxy)benzonitrile

There total 3 articles about 2-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-4-(methoxymethoxy)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1333263-20-9
2-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-4-hydroxybenzonitrile

: 107-30-2
chloromethyl methyl ether

: 1333263-46-9
2-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-4-(methoxymethoxy)benzonitrile

Guidance literature:: 2-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-4-hydroxybenzonitrile; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

chloromethyl methyl ether; In N,N-dimethyl-formamide; at 20 ℃; for 0.166667h;

Reference yield:

: 3336-16-1
2-chloro-4-hydroxybenzonitrile

: 1333263-46-9
2-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-4-(methoxymethoxy)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium phosphate; 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl / palladium diacetate / 1,4-dioxane; water / 16 h / 100 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 0.17 h / 20 °C

With potassium phosphate; 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl; sodium hydride; palladium diacetate; In 1,4-dioxane; water; N,N-dimethyl-formamide;

Reference yield:

: 1333263-19-6
1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxide

: 1333263-46-9
2-{1-[(2,2-difluorocyclopropyl)methyl]-3-methyl-2,2-dioxido-1,3-dihydro-2,1,3-benzothiadiazol-5-yl}-4-(methoxymethoxy)benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: potassium phosphate; 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl / palladium diacetate / 1,4-dioxane; water / 16 h / 100 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 0.17 h / 20 °C

With potassium phosphate; 2-dicyclohexylphosphino-2′,6′-dimethoxybiphenyl; sodium hydride; palladium diacetate; In 1,4-dioxane; water; N,N-dimethyl-formamide;