(3aS,7aR)-3a-(3,4-dimethoxyphenyl)-1-[(R)-1-(1,2,3,4-tetrahydronaphthalen-5-yl)ethyl]octahydroindole

Base Information

Chemical Name:(3aS,7aR)-3a-(3,4-dimethoxyphenyl)-1-[(R)-1-(1,2,3,4-tetrahydronaphthalen-5-yl)ethyl]octahydroindole
CAS No.:943229-29-6
Molecular Formula:C₂₈H₃₇NO₂
Molecular Weight:419.607
Hs Code.:

Synonyms:(3aS,7aR)-3a-(3,4-dimethoxyphenyl)-1-[(R)-1-(1,2,3,4-tetrahydronaphthalen-5-yl)ethyl]octahydroindole

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Chemical Property of (3aS,7aR)-3a-(3,4-dimethoxyphenyl)-1-[(R)-1-(1,2,3,4-tetrahydronaphthalen-5-yl)ethyl]octahydroindole

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Technology Process of (3aS,7aR)-3a-(3,4-dimethoxyphenyl)-1-[(R)-1-(1,2,3,4-tetrahydronaphthalen-5-yl)ethyl]octahydroindole

There total 7 articles about (3aS,7aR)-3a-(3,4-dimethoxyphenyl)-1-[(R)-1-(1,2,3,4-tetrahydronaphthalen-5-yl)ethyl]octahydroindole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 943229-26-3
(3aS,7aR)-3a-(3,4-dimethoxyphenyl)-1-[(R)-1-(1,2,3,4-tetrahydronaphthalen-5-yl)ethyl]octahydroindol-2-one

: 943229-29-6
(3aS,7aR)-3a-(3,4-dimethoxyphenyl)-1-[(R)-1-(1,2,3,4-tetrahydronaphthalen-5-yl)ethyl]octahydroindole

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 1h; Heating;
DOI:10.1016/j.tet.2007.03.153

Reference yield:

: C₂₆H₂₉NO₂

: 943229-29-6
(3aS,7aR)-3a-(3,4-dimethoxyphenyl)-1-[(R)-1-(1,2,3,4-tetrahydronaphthalen-5-yl)ethyl]octahydroindole

Guidance literature:: Multi-step reaction with 5 steps

1: 1.05 g / N,N-dimethylaniline; 4-dimethylaminopyridine / toluene / 13 h / 60 °C

2: 59 percent / N-chlorosuccinimide / CCl₄ / 1 h / 20 °C

3: 94 percent / Raney nickel / ethanol / 1 h / Heating

4: 54 percent / H₂ / platinum dioxide / acetic acid / 14 h / 20 °C

5: 74 percent / LiAlH₄ / tetrahydrofuran / 1 h / Heating

With dmap; N-chloro-succinimide; lithium aluminium tetrahydride; hydrogen; N,N-dimethyl-aniline; platinum(IV) oxide; nickel; In tetrahydrofuran; tetrachloromethane; ethanol; acetic acid; toluene;
DOI:10.1016/j.tet.2007.03.153

Reference yield:

: 926013-34-5
N-[2-(3,4-dimethoxyphenyl)cyclohexen-1-yl]-α-(methylthio)-N-[(R)-1-(1-naphtyhl)ethyl]acetamide

: 943229-29-6
(3aS,7aR)-3a-(3,4-dimethoxyphenyl)-1-[(R)-1-(1,2,3,4-tetrahydronaphthalen-5-yl)ethyl]octahydroindole

Guidance literature:: Multi-step reaction with 4 steps

1: 59 percent / N-chlorosuccinimide / CCl₄ / 1 h / 20 °C

2: 94 percent / Raney nickel / ethanol / 1 h / Heating

3: 54 percent / H₂ / platinum dioxide / acetic acid / 14 h / 20 °C

4: 74 percent / LiAlH₄ / tetrahydrofuran / 1 h / Heating

With N-chloro-succinimide; lithium aluminium tetrahydride; hydrogen; platinum(IV) oxide; nickel; In tetrahydrofuran; tetrachloromethane; ethanol; acetic acid;
DOI:10.1016/j.tet.2007.03.153