ethyl 5-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxothieno[3,4-d]pyrimidin-1-yl]pentanoate

Base Information

• Chemical Name: ethyl 5-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxothieno[3,4-d]pyrimidin-1-yl]pentanoate
• CAS No.: 130475-84-2
• Molecular Formula: C₂₆H₃₄N₄O₅S
• Molecular Weight: 514.646
• Mol file: 130475-84-2.mol

Synonyms:ethyl 5-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxothieno[3,4-d]pyrimidin-1-yl]pentanoate

Chemical Property of ethyl 5-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxothieno[3,4-d]pyrimidin-1-yl]pentanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 5-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxothieno[3,4-d]pyrimidin-1-yl]pentanoate

There total 4 articles about ethyl 5-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxothieno[3,4-d]pyrimidin-1-yl]pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

2-bromo-pentanoic acid ethyl ester (615-83-8) + 3-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<3,4-d>pyrimidine-2,4-dione (110164-06-2) → ethyl 5-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxothieno[3,4-d]pyrimidin-1-yl]pentanoate (130475-84-2)

Guidance literature:

In NaH; N,N-dimethyl-formamide;

Reference yield:

methyl 3-amino-4-thiophenecarboxylate hydrochloride (39978-14-8) → ethyl 5-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxothieno[3,4-d]pyrimidin-1-yl]pentanoate (130475-84-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 84 percent / aq. NaOH / CH₂Cl₂ / 2 h / Ambient temperature

2: 36 percent / AlMe₃ / toluene / 0 --> 100 degC

3: 1.) NaH / 1.) DMF, r.t., 2.) r.t.

With sodium hydroxide; trimethylaluminum; sodium hydride; In dichloromethane; toluene;

Reference yield:

ethyl (4-methoxycarbonyl)thiophene-3-carbamate (118252-16-7) → ethyl 5-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]ethyl]-2,4-dioxothieno[3,4-d]pyrimidin-1-yl]pentanoate (130475-84-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 36 percent / AlMe₃ / toluene / 0 --> 100 degC

2: 1.) NaH / 1.) DMF, r.t., 2.) r.t.

With trimethylaluminum; sodium hydride; In toluene;

upstream raw materials:

ethyl 5-bromovalerate

3-<2-<4-(2-methoxyphenyl)piperazin-1-yl>ethyl>thieno<3,4-d>pyrimidine-2,4-dione

methyl 3-amino-4-thiophenecarboxylate hydrochloride

ethyl (4-methoxycarbonyl)thiophene-3-carbamate

Downstream raw materials:

4-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-6,7,8,9-tetrahydro-1-thia-4,5a-diaza-cycloocta[cd]indene-3,5,10-trione

3-[3-[2-[4-(2-methoxyphenyl)piperazin-1-yl]-ethyl]-5-methyl-2,4-dioxothieno[3,4-d]pyrimidin-1-yl]-propanoic acid sodium salt

5-(3-{2-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-ethyl}-2,4-dioxo-3,4-dihydro-2H-thieno[3,4-d]pyrimidin-1-yl)-pentanoic acid