4-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methyl)phenyl phosphonic acid

Base Information

Chemical Name:4-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methyl)phenyl phosphonic acid
CAS No.:1428526-24-2
Molecular Formula:C₂₃H₁₉N₄O₅P
Molecular Weight:462.401
Hs Code.:

Synonyms:4-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methyl)phenyl phosphonic acid

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Chemical Property of 4-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methyl)phenyl phosphonic acid

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Technology Process of 4-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methyl)phenyl phosphonic acid

There total 11 articles about 4-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methyl)phenyl phosphonic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 1428526-23-1
diethyl 4-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methyl)phenylphosphonate

: 1428526-24-2
4-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methyl)phenyl phosphonic acid

Guidance literature:: With trimethylsilyl bromide; In dichloromethane; at 20 ℃; for 48h;

Reference yield:

: 90-90-4
(4-bromophenyl)(phenyl)methanone

: 1428526-24-2
4-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methyl)phenyl phosphonic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: 24 h / 185 °C

2.1: potassium hydroxide / methanol / 8 h / Reflux

3.1: triethylamine / dichloromethane / 0 °C

3.2: 20 °C

4.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / toluene / Reflux

5.1: hydrogenchloride / 1,4-dioxane / 20 °C

6.1: triethylamine; HATU / acetonitrile / 2 h / 20 °C

7.1: trimethylsilyl bromide / dichloromethane / 48 h / 20 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; trimethylsilyl bromide; triethylamine; HATU; potassium hydroxide; In 1,4-dioxane; methanol; dichloromethane; toluene; acetonitrile;

Reference yield:

: 55095-17-5,220441-81-6
(4-bromophenyl)(phenyl)methanamine

: 1428526-24-2
4-((4-hydroxy-2-(pyridin-2-yl)pyrimidine-5-carboxamido)(phenyl)methyl)phenyl phosphonic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / dichloromethane / 0 °C

1.2: 20 °C

2.1: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; triethylamine / toluene / Reflux

3.1: hydrogenchloride / 1,4-dioxane / 20 °C

4.1: triethylamine; HATU / acetonitrile / 2 h / 20 °C

5.1: trimethylsilyl bromide / dichloromethane / 48 h / 20 °C

With hydrogenchloride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; trimethylsilyl bromide; triethylamine; HATU; In 1,4-dioxane; dichloromethane; toluene; acetonitrile;