diphenylmethyl (6R,7S)-7-(phenoxyacetamido)-3-phenylceph-3-em-4-carboxylate

Base Information

Chemical Name:diphenylmethyl (6R,7S)-7-(phenoxyacetamido)-3-phenylceph-3-em-4-carboxylate
CAS No.:130516-12-0
Molecular Formula:C₃₄H₂₈N₂O₅S
Molecular Weight:576.673
Hs Code.:

Synonyms:diphenylmethyl (6R,7S)-7-(phenoxyacetamido)-3-phenylceph-3-em-4-carboxylate

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Chemical Property of diphenylmethyl (6R,7S)-7-(phenoxyacetamido)-3-phenylceph-3-em-4-carboxylate

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Technology Process of diphenylmethyl (6R,7S)-7-(phenoxyacetamido)-3-phenylceph-3-em-4-carboxylate

There total 11 articles about diphenylmethyl (6R,7S)-7-(phenoxyacetamido)-3-phenylceph-3-em-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 143159-86-8
Diphenylmethyl 2-<(3R,4R)-4-<(p-toluenesulfonyl)thio>-3-(phenoxyacetamido)-2-oxoazetidin-1-yl>-2,3-butadienoate

: 130516-12-0
diphenylmethyl (6R,7S)-7-(phenoxyacetamido)-3-phenylceph-3-em-4-carboxylate

Guidance literature:: In tetrahydrofuran; at -78 ℃; for 0.25h;
DOI:10.1016/S0040-4039(00)92503-6

Reference yield: 65.0%

: 23402-69-9
lithium diphenylcuprate

: 130516-07-3
diphenylmethyl (6R,7S)-7-(phenoxyacetamido)-3-<<(trifluoromethyl)sulfonyl>oxy>ceph-3-em-4-carboxylate

: 130516-12-0
diphenylmethyl (6R,7S)-7-(phenoxyacetamido)-3-phenylceph-3-em-4-carboxylate

Guidance literature:: With boron trifluoride diethyl etherate; In tetrahydrofuran; at -78 ℃;
DOI:10.1016/S0040-4039(00)97404-5

Reference yield:

: 57561-96-3
diphenylmethyl 3-hydroxy-2-<(3R,4R)-2-oxo-3-(phenoxyacetylamino)-4-(p-tolylsulfonylthio)-1-azetidinyl>-2-butenoate

: 130516-12-0
diphenylmethyl (6R,7S)-7-(phenoxyacetamido)-3-phenylceph-3-em-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 86.5 percent / i-Pr₂NEt / CH₂Cl₂ / 1 h / -78 °C

2: 100 percent / TEA / CH₂Cl₂ / 1 h / Ambient temperature

3: 1.) CuI / 1.) THF, 15 min, 2.) THF, -78 deg C, 20 min

With copper(l) iodide; TEA; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1021/jo00096a045