N-{(S)-1-Benzyl-2-[(S)-2-(cyclohexylcarbamoyl-hydroxy-methyl)-pyrrolidin-1-yl]-2-oxo-ethyl}-3-cyclohexyl-propionamide

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Chemical Name:N-{(S)-1-Benzyl-2-[(S)-2-(cyclohexylcarbamoyl-hydroxy-methyl)-pyrrolidin-1-yl]-2-oxo-ethyl}-3-cyclohexyl-propionamide
CAS No.:453509-74-5
Molecular Formula:C₃₀H₄₅N₃O₄
Molecular Weight:511.705
Hs Code.:

Synonyms:N-{(S)-1-Benzyl-2-[(S)-2-(cyclohexylcarbamoyl-hydroxy-methyl)-pyrrolidin-1-yl]-2-oxo-ethyl}-3-cyclohexyl-propionamide

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Chemical Property of N-{(S)-1-Benzyl-2-[(S)-2-(cyclohexylcarbamoyl-hydroxy-methyl)-pyrrolidin-1-yl]-2-oxo-ethyl}-3-cyclohexyl-propionamide

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Technology Process of N-{(S)-1-Benzyl-2-[(S)-2-(cyclohexylcarbamoyl-hydroxy-methyl)-pyrrolidin-1-yl]-2-oxo-ethyl}-3-cyclohexyl-propionamide

There total 9 articles about N-{(S)-1-Benzyl-2-[(S)-2-(cyclohexylcarbamoyl-hydroxy-methyl)-pyrrolidin-1-yl]-2-oxo-ethyl}-3-cyclohexyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 701-97-3
cyclohexanepropionic acid

: 2-[(S)-1-((S)-2-Amino-3-phenyl-propionyl)-pyrrolidin-2-yl]-N-cyclohexyl-2-hydroxy-acetamide

: 453509-74-5
N-{(S)-1-Benzyl-2-[(S)-2-(cyclohexylcarbamoyl-hydroxy-methyl)-pyrrolidin-1-yl]-2-oxo-ethyl}-3-cyclohexyl-propionamide

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In dichloromethane;
DOI:10.1016/S0040-4039(02)00728-1

Reference yield:

: 69610-40-8
N-(tert-butoxycarbonyl)-L-prolinol

: 453509-74-5
N-{(S)-1-Benzyl-2-[(S)-2-(cyclohexylcarbamoyl-hydroxy-methyl)-pyrrolidin-1-yl]-2-oxo-ethyl}-3-cyclohexyl-propionamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: 83 percent / CH₂Cl₂ / 24 h / 20 °C

2.1: CF₃CO₂H

2.2: Et₃N

3.1: 62 percent / py-BOP; Et₃N / CH₂Cl₂

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; trifluoroacetic acid; In dichloromethane; 1.1: Swern oxidation / 2.1: Passerini reaction;
DOI:10.1016/S0040-4039(02)00728-1

Reference yield:

: 453509-73-4
2-[(2-tert-butoxycarbonylamino-3-phenyl-propionyloxy)-cyclohexylcarbamoyl-methyl]-pyrrolidine-1-carboxylic acid tert-butyl ester

: 453509-74-5
N-{(S)-1-Benzyl-2-[(S)-2-(cyclohexylcarbamoyl-hydroxy-methyl)-pyrrolidin-1-yl]-2-oxo-ethyl}-3-cyclohexyl-propionamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: CF₃CO₂H

1.2: Et₃N

2.1: 62 percent / py-BOP; Et₃N / CH₂Cl₂

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; trifluoroacetic acid; In dichloromethane;
DOI:10.1016/S0040-4039(02)00728-1