(S)-2-(4-methanesulphonylpiperazin-1-yl)-3-(4-methoxybenzoylamino)propanoic acid

Base Information

Chemical Name:(S)-2-(4-methanesulphonylpiperazin-1-yl)-3-(4-methoxybenzoylamino)propanoic acid
CAS No.:1271521-46-0
Molecular Formula:C₁₆H₂₃N₃O₆S
Molecular Weight:385.441
Hs Code.:

Synonyms:(S)-2-(4-methanesulphonylpiperazin-1-yl)-3-(4-methoxybenzoylamino)propanoic acid

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Chemical Property of (S)-2-(4-methanesulphonylpiperazin-1-yl)-3-(4-methoxybenzoylamino)propanoic acid

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Technology Process of (S)-2-(4-methanesulphonylpiperazin-1-yl)-3-(4-methoxybenzoylamino)propanoic acid

There total 9 articles about (S)-2-(4-methanesulphonylpiperazin-1-yl)-3-(4-methoxybenzoylamino)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1271521-45-9
methyl (S)-2-(4-methanesulphonylpiperazin-1-yl)-3-(4-methoxybenzoylamino)propanoate

: 1271521-46-0
(S)-2-(4-methanesulphonylpiperazin-1-yl)-3-(4-methoxybenzoylamino)propanoic acid

Guidance literature:: methyl (S)-2-(4-methanesulphonylpiperazin-1-yl)-3-(4-methoxybenzoylamino)propanoate; With water; lithium hydroxide; In tetrahydrofuran; at 20 ℃; for 20h;

With hydrogenchloride; In water; pH=6;

Reference yield:

: 99-76-3,156291-94-0
methyl 4-hydroxylbenzoate

: 1271521-46-0
(S)-2-(4-methanesulphonylpiperazin-1-yl)-3-(4-methoxybenzoylamino)propanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / N,N-dimethyl-formamide; tetrahydrofuran / 0.33 h / 20 °C

1.2: 24 h / 20 °C

2.1: sodium hydroxide; water / tetrahydrofuran; methanol / 18 h / 40 °C

2.2: pH 6

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.33 h

3.2: 19.5 h / 20 - 50 °C

4.1: sulfuric acid / tetrahydrofuran; methanol / 18 h / 20 °C

5.1: potassium carbonate / butanone / 4 h / 80 °C

6.1: water; lithium hydroxide / tetrahydrofuran / 20 h / 20 °C

6.2: pH 6

With sulfuric acid; water; sodium hydride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; butanone;

Reference yield:

: 54533-09-4
N,N-bis(2-chloroethyl)methanesulfonamide

: 1271521-46-0
(S)-2-(4-methanesulphonylpiperazin-1-yl)-3-(4-methoxybenzoylamino)propanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: N-ethyl-N,N-diisopropylamine / 18 h / 127 °C

2.1: hydrogenchloride / isopropyl alcohol; methanol / 2 h / 40 °C

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol / N,N-dimethyl-formamide / 0.33 h

3.2: 19.5 h / 20 - 50 °C

4.1: sulfuric acid / tetrahydrofuran; methanol / 18 h / 20 °C

5.1: potassium carbonate / butanone / 4 h / 80 °C

6.1: water; lithium hydroxide / tetrahydrofuran / 20 h / 20 °C

6.2: pH 6

With hydrogenchloride; sulfuric acid; water; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; isopropyl alcohol; butanone;