2-cyclohexyl-2-(2-phenyl-1H-benzo[d]imidazol-1-yl)ethyl 1-(1-(thiophen-3-ylmethyl)-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxylate

Base Information

Chemical Name:2-cyclohexyl-2-(2-phenyl-1H-benzo[d]imidazol-1-yl)ethyl 1-(1-(thiophen-3-ylmethyl)-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxylate
CAS No.:1565835-92-8
Molecular Formula:C₃₉H₄₁N₅O₂S
Molecular Weight:643.853
Hs Code.:

Synonyms:2-cyclohexyl-2-(2-phenyl-1H-benzo[d]imidazol-1-yl)ethyl 1-(1-(thiophen-3-ylmethyl)-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxylate

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Chemical Property of 2-cyclohexyl-2-(2-phenyl-1H-benzo[d]imidazol-1-yl)ethyl 1-(1-(thiophen-3-ylmethyl)-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxylate

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Technology Process of 2-cyclohexyl-2-(2-phenyl-1H-benzo[d]imidazol-1-yl)ethyl 1-(1-(thiophen-3-ylmethyl)-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxylate

There total 10 articles about 2-cyclohexyl-2-(2-phenyl-1H-benzo[d]imidazol-1-yl)ethyl 1-(1-(thiophen-3-ylmethyl)-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1440753-69-4
2-cyclohexyl-2-(2-phenyl-1H-benzo[d]imidazol-1-yl)ethanol

: 1440754-34-6
1-(1-(thiophen-3-ylmethyl)-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxylic acid

: 1565835-92-8
2-cyclohexyl-2-(2-phenyl-1H-benzo[d]imidazol-1-yl)ethyl 1-(1-(thiophen-3-ylmethyl)-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxylate

Guidance literature:: With di-tert-butyl azodicarboxylate; In tetrahydrofuran; at 20 - 100 ℃; for 0.5h;
DOI:10.1021/jm500632s

Reference yield:

: 1440753-49-0
N-benzyl-2-cyclohexyl-2-(2-phenyl-1H-benzo[d]imidazol-1-yl)acetamide

: 1565835-92-8
2-cyclohexyl-2-(2-phenyl-1H-benzo[d]imidazol-1-yl)ethyl 1-(1-(thiophen-3-ylmethyl)-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine; dmap / 36 h / 20 °C

2: sodium tetrahydroborate / tetrahydrofuran; ethanol / 15 h / 20 °C

3: di-tert-butyl azodicarboxylate / tetrahydrofuran / 0.5 h / 20 - 100 °C

With dmap; sodium tetrahydroborate; di-tert-butyl azodicarboxylate; triethylamine; In tetrahydrofuran; ethanol; 3: |Mitsunobu Displacement;
DOI:10.1021/jm500632s

Reference yield:

: 1440753-57-0
tert-butyl benzyl(2-cyclohexyl-2-(2-phenyl-1H-benzo[d]imidazol-1-yl)acetyl)carbamate

: 1565835-92-8
2-cyclohexyl-2-(2-phenyl-1H-benzo[d]imidazol-1-yl)ethyl 1-(1-(thiophen-3-ylmethyl)-1H-benzo[d]imidazol-2-yl)piperidine-4-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium tetrahydroborate / tetrahydrofuran; ethanol / 15 h / 20 °C

2: di-tert-butyl azodicarboxylate / tetrahydrofuran / 0.5 h / 20 - 100 °C

With sodium tetrahydroborate; di-tert-butyl azodicarboxylate; In tetrahydrofuran; ethanol; 2: |Mitsunobu Displacement;
DOI:10.1021/jm500632s