N-(3-amino-5-(2-oxo-2,3-dihydrothiazol-4-yl)phenyl)thiophene-2-sulfonamide

Base Information

Chemical Name:N-(3-amino-5-(2-oxo-2,3-dihydrothiazol-4-yl)phenyl)thiophene-2-sulfonamide
CAS No.:1435385-98-0
Molecular Formula:C₁₃H₁₁N₃O₃S₃
Molecular Weight:353.447
Hs Code.:

Synonyms:N-(3-amino-5-(2-oxo-2,3-dihydrothiazol-4-yl)phenyl)thiophene-2-sulfonamide

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Chemical Property of N-(3-amino-5-(2-oxo-2,3-dihydrothiazol-4-yl)phenyl)thiophene-2-sulfonamide

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Technology Process of N-(3-amino-5-(2-oxo-2,3-dihydrothiazol-4-yl)phenyl)thiophene-2-sulfonamide

There total 6 articles about N-(3-amino-5-(2-oxo-2,3-dihydrothiazol-4-yl)phenyl)thiophene-2-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

: 16629-19-9
thiophene-2-sulfonyl chloride

: 1176070-02-2
4-(3-aminophenyl)thiazol-2(3H)-one

: 1435385-98-0
N-(3-amino-5-(2-oxo-2,3-dihydrothiazol-4-yl)phenyl)thiophene-2-sulfonamide

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/jm301793a

Reference yield:

: 121-89-1
3-Nitroacetophenone

: 1435385-98-0
N-(3-amino-5-(2-oxo-2,3-dihydrothiazol-4-yl)phenyl)thiophene-2-sulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: copper(ll) bromide / ethyl acetate / Reflux; Inert atmosphere

2: acetone / 0.5 h / 20 °C / Inert atmosphere

3: sulfuric acid; acetic acid / 1 h / 100 °C / Inert atmosphere

4: iron; ammonium chloride / ethanol / 1 h / 80 °C / Inert atmosphere

5: pyridine / dichloromethane / 2 h / 20 °C / Inert atmosphere

With pyridine; sulfuric acid; iron; ammonium chloride; acetic acid; copper(ll) bromide; In ethanol; dichloromethane; ethyl acetate; acetone;
DOI:10.1021/jm301793a

Reference yield:

: 2227-64-7
3'-nitro-2-bromoacetophenone

: 1435385-98-0
N-(3-amino-5-(2-oxo-2,3-dihydrothiazol-4-yl)phenyl)thiophene-2-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: acetone / 0.5 h / 20 °C / Inert atmosphere

2: sulfuric acid; acetic acid / 1 h / 100 °C / Inert atmosphere

3: iron; ammonium chloride / ethanol / 1 h / 80 °C / Inert atmosphere

4: pyridine / dichloromethane / 2 h / 20 °C / Inert atmosphere

With pyridine; sulfuric acid; iron; ammonium chloride; acetic acid; In ethanol; dichloromethane; acetone;
DOI:10.1021/jm301793a