(2S,6S,7R)-7-(1-ethoxyethoxy)-6-ethyl-2-{(4R,5R,6S)-6-[(S)-2-(4-methoxybenzyloxy-1-methylethyl)]-2,2,5-trimethyl-1,3-dioxan-4-yl}-4-octyn-3-one

Base Information

Chemical Name:(2S,6S,7R)-7-(1-ethoxyethoxy)-6-ethyl-2-{(4R,5R,6S)-6-[(S)-2-(4-methoxybenzyloxy-1-methylethyl)]-2,2,5-trimethyl-1,3-dioxan-4-yl}-4-octyn-3-one
CAS No.:906360-45-0
Molecular Formula:C₃₂H₅₀O₇
Molecular Weight:546.745
Hs Code.:

Synonyms:(2S,6S,7R)-7-(1-ethoxyethoxy)-6-ethyl-2-{(4R,5R,6S)-6-[(S)-2-(4-methoxybenzyloxy-1-methylethyl)]-2,2,5-trimethyl-1,3-dioxan-4-yl}-4-octyn-3-one

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Chemical Property of (2S,6S,7R)-7-(1-ethoxyethoxy)-6-ethyl-2-{(4R,5R,6S)-6-[(S)-2-(4-methoxybenzyloxy-1-methylethyl)]-2,2,5-trimethyl-1,3-dioxan-4-yl}-4-octyn-3-one

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Technology Process of (2S,6S,7R)-7-(1-ethoxyethoxy)-6-ethyl-2-{(4R,5R,6S)-6-[(S)-2-(4-methoxybenzyloxy-1-methylethyl)]-2,2,5-trimethyl-1,3-dioxan-4-yl}-4-octyn-3-one

There total 16 articles about (2S,6S,7R)-7-(1-ethoxyethoxy)-6-ethyl-2-{(4R,5R,6S)-6-[(S)-2-(4-methoxybenzyloxy-1-methylethyl)]-2,2,5-trimethyl-1,3-dioxan-4-yl}-4-octyn-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 906360-43-8
(2R,6S,7R)-7-(2-Ethoxy-ethoxy)-6-ethyl-2-{(4S,5R,6S)-6-[(S)-2-(4-methoxy-benzyloxy)-1-methyl-ethyl]-2,2,5-trimethyl-[1,3]dioxan-4-yl}-oct-4-yn-3-ol

: 906360-45-0
(2S,6S,7R)-7-(1-ethoxyethoxy)-6-ethyl-2-{(4R,5R,6S)-6-[(S)-2-(4-methoxybenzyloxy-1-methylethyl)]-2,2,5-trimethyl-1,3-dioxan-4-yl}-4-octyn-3-one

Guidance literature:: With Dess-Martin periodane; In dichloromethane; at 0 ℃; for 24h;
DOI:10.1002/chem.200600134

Reference yield: 83.0%

: 906360-41-6
(3S,4R)-4-(1-ethoxyethoxy)-3-ethyl-1-pentene

: 906360-46-1
S-dodecyl (S)-2-{(4R,5R,6S)-6-[(S)-2-(4-methoxybenzyloxy)-1-methylethyl]-2,2,5-trimethyl-1,3-dioxan-4-yl}propanethioate

: 906360-45-0
(2S,6S,7R)-7-(1-ethoxyethoxy)-6-ethyl-2-{(4R,5R,6S)-6-[(S)-2-(4-methoxybenzyloxy-1-methylethyl)]-2,2,5-trimethyl-1,3-dioxan-4-yl}-4-octyn-3-one

Guidance literature:: With copper(l) iodide; trifuran-2-yl-phosphane; triethylamine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In N,N-dimethyl-formamide; at 50 ℃; for 3h;
DOI:10.1002/chem.200600134

Reference yield:

: 906360-30-3
methyl (2R,3R)-3-(1-ethoxyethoxy)-2-ethylbutanoate

: 906360-45-0
(2S,6S,7R)-7-(1-ethoxyethoxy)-6-ethyl-2-{(4R,5R,6S)-6-[(S)-2-(4-methoxybenzyloxy-1-methylethyl)]-2,2,5-trimethyl-1,3-dioxan-4-yl}-4-octyn-3-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: 100 percent / DIBAL / CH₂Cl₂; hexane / 48 h / -78 - 20 °C

2.1: 100 percent / oxalyl chloride; DMSO; Et₃N / CH₂Cl₂ / 2 h / -78 °C

3.1: PPh₃; pyridine / CH₂Cl₂ / 0.25 h / 0 °C

3.2: 64 percent / CH₂Cl₂ / 1.5 h / 0 °C

4.1: 79 percent / n-BuLi / tetrahydrofuran; hexane / 24 h / -78 °C

5.1: 83 percent / CuI; tri(2-furyl)phosphine; Et₃N / [PdCl₂(dppf)] / dimethylformamide / 3 h / 50 °C

With pyridine; copper(l) iodide; n-butyllithium; oxalyl dichloride; trifuran-2-yl-phosphane; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; triphenylphosphine; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide; 2.1: Swern oxidation;
DOI:10.1002/chem.200600134