N-{4-[2-(4-aminophenyl)ethyl]-5-[4-(aminosulfonyl)benzyl]-1,3-thiazol-2-yl}acetamide

Base Information

Chemical Name:N-{4-[2-(4-aminophenyl)ethyl]-5-[4-(aminosulfonyl)benzyl]-1,3-thiazol-2-yl}acetamide
CAS No.:874899-61-3
Molecular Formula:C₂₀H₂₂N₄O₃S₂
Molecular Weight:430.552
Hs Code.:

Synonyms:N-{4-[2-(4-aminophenyl)ethyl]-5-[4-(aminosulfonyl)benzyl]-1,3-thiazol-2-yl}acetamide

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Chemical Property of N-{4-[2-(4-aminophenyl)ethyl]-5-[4-(aminosulfonyl)benzyl]-1,3-thiazol-2-yl}acetamide

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Technology Process of N-{4-[2-(4-aminophenyl)ethyl]-5-[4-(aminosulfonyl)benzyl]-1,3-thiazol-2-yl}acetamide

There total 12 articles about N-{4-[2-(4-aminophenyl)ethyl]-5-[4-(aminosulfonyl)benzyl]-1,3-thiazol-2-yl}acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₀H₂₀N₄O₅S₂

: 874899-61-3
N-{4-[2-(4-aminophenyl)ethyl]-5-[4-(aminosulfonyl)benzyl]-1,3-thiazol-2-yl}acetamide

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In methanol; acetic acid; at 25 ℃; for 15h;

Reference yield:

: C₂₀H₁₈N₄O₅S₂

: 874899-61-3
N-{4-[2-(4-aminophenyl)ethyl]-5-[4-(aminosulfonyl)benzyl]-1,3-thiazol-2-yl}acetamide

Guidance literature:: C₂₀H₁₈N₄O₅S₂; With palladium 10% on activated carbon; hydrogen; acetic acid; In methanol; at 20 ℃; for 15h; under 2280.15 Torr;

With sodium hydroxide; In methanol; water;
DOI:10.1016/j.bmc.2013.02.048

Reference yield:

: 737824-41-8
ethyl 2-(acetylamino)-5-benzyl-1,3-thiazole-4-carboxylate

: 874899-61-3
N-{4-[2-(4-aminophenyl)ethyl]-5-[4-(aminosulfonyl)benzyl]-1,3-thiazol-2-yl}acetamide

Guidance literature:: Multi-step reaction with 6 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 20 °C / Inert atmosphere

2: manganese(IV) oxide / methanol; chloroform / 13 h / 20 °C / Inert atmosphere

3: potassium tert-butylate / N,N-dimethyl-formamide / 0 - 20 °C / Inert atmosphere

4: chlorosulfonic acid / chloroform / 20 °C / Cooling with ice

5: ammonium hydroxide / water; tetrahydrofuran / 5 - 20 °C

6: acetic acid; palladium 10% on activated carbon; hydrogen / methanol / 15 h / 20 °C / 2280.15 Torr

With chlorosulfonic acid; manganese(IV) oxide; ammonium hydroxide; lithium aluminium tetrahydride; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; acetic acid; In tetrahydrofuran; methanol; chloroform; water; N,N-dimethyl-formamide; 3: |Wittig Olefination;
DOI:10.1016/j.bmc.2013.02.048