(R)-1-[(4R,5S)-5-{(S)-1-[allyl(benzyl)amino]but-3-enyl}-2,2-dimethyl-1,3-dioxolan-4-yl]-2-(tert-butyldimethylsilyloxy)ethanol

Base Information

Chemical Name:(R)-1-[(4R,5S)-5-{(S)-1-[allyl(benzyl)amino]but-3-enyl}-2,2-dimethyl-1,3-dioxolan-4-yl]-2-(tert-butyldimethylsilyloxy)ethanol
CAS No.:1430411-24-7
Molecular Formula:C₂₇H₄₅NO₄Si
Molecular Weight:475.744
Hs Code.:

Synonyms:(R)-1-[(4R,5S)-5-{(S)-1-[allyl(benzyl)amino]but-3-enyl}-2,2-dimethyl-1,3-dioxolan-4-yl]-2-(tert-butyldimethylsilyloxy)ethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-1-[(4R,5S)-5-{(S)-1-[allyl(benzyl)amino]but-3-enyl}-2,2-dimethyl-1,3-dioxolan-4-yl]-2-(tert-butyldimethylsilyloxy)ethanol

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Technology Process of (R)-1-[(4R,5S)-5-{(S)-1-[allyl(benzyl)amino]but-3-enyl}-2,2-dimethyl-1,3-dioxolan-4-yl]-2-(tert-butyldimethylsilyloxy)ethanol

There total 2 articles about (R)-1-[(4R,5S)-5-{(S)-1-[allyl(benzyl)amino]but-3-enyl}-2,2-dimethyl-1,3-dioxolan-4-yl]-2-(tert-butyldimethylsilyloxy)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 1233851-78-9
(R)-1-((4R,5S)-5-((S)-1-(benzylamino)-but-3-enyl)-2,2-dimethyl-1,3-dioxolan-4-yl)-2-(tert-butyl-dimethylsilyloxy)ethanol

: 106-95-6
allyl bromide

: 1430411-24-7
(R)-1-[(4R,5S)-5-{(S)-1-[allyl(benzyl)amino]but-3-enyl}-2,2-dimethyl-1,3-dioxolan-4-yl]-2-(tert-butyldimethylsilyloxy)ethanol

Guidance literature:: With potassium carbonate; In acetonitrile; at 0 ℃; for 12h; chemoselective reaction; Reflux;
DOI:10.1002/ejoc.201201342

Reference yield:

: 1233851-77-8
C₂₁H₃₅NO₄Si

: 1430411-24-7
(R)-1-[(4R,5S)-5-{(S)-1-[allyl(benzyl)amino]but-3-enyl}-2,2-dimethyl-1,3-dioxolan-4-yl]-2-(tert-butyldimethylsilyloxy)ethanol

Guidance literature:: Multi-step reaction with 2 steps

1: zinc / tetrahydrofuran / 0 - 20 °C

2: potassium carbonate / acetonitrile / 12 h / 0 °C / Reflux

With potassium carbonate; zinc; In tetrahydrofuran; acetonitrile;
DOI:10.1002/ejoc.201201342