benzoic acid 5-(S)-amino-2-(S)-(1-(S)-carboxy-ethylcarbamoyl)-4-oxo-6-phenyl-hexyl ester trifluoroacetate

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Chemical Name:benzoic acid 5-(S)-amino-2-(S)-(1-(S)-carboxy-ethylcarbamoyl)-4-oxo-6-phenyl-hexyl ester trifluoroacetate
CAS No.:1322615-33-7
Molecular Formula:C₂HF₃O₂*C₂₃H₂₆N₂O₆
Molecular Weight:540.493
Hs Code.:

Synonyms:benzoic acid 5-(S)-amino-2-(S)-(1-(S)-carboxy-ethylcarbamoyl)-4-oxo-6-phenyl-hexyl ester trifluoroacetate

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Chemical Property of benzoic acid 5-(S)-amino-2-(S)-(1-(S)-carboxy-ethylcarbamoyl)-4-oxo-6-phenyl-hexyl ester trifluoroacetate

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Technology Process of benzoic acid 5-(S)-amino-2-(S)-(1-(S)-carboxy-ethylcarbamoyl)-4-oxo-6-phenyl-hexyl ester trifluoroacetate

There total 6 articles about benzoic acid 5-(S)-amino-2-(S)-(1-(S)-carboxy-ethylcarbamoyl)-4-oxo-6-phenyl-hexyl ester trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1322615-74-6
benzoic acid 5-(S)-benzyloxycarbonylamino-2-(S)-(1-(S)-benzyloxycarbonyl-ethylcarbamoyl)-4-oxo-6-phenyl-hexyl ester

: 76-05-1
trifluoroacetic acid

: 1322615-33-7
benzoic acid 5-(S)-amino-2-(S)-(1-(S)-carboxy-ethylcarbamoyl)-4-oxo-6-phenyl-hexyl ester trifluoroacetate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.bmcl.2011.05.108

Reference yield:

: 1322615-29-1
benzoic acid 2-(S)-(4-(R)-benzyl-2-oxo-oxazolidine-3-carbonyl)-5-(S)-[benzyloxycarbonyl-(4-methoxy-benzyl)-amino]-4-oxo-6-phenyl-hexyl ester

: 1322615-33-7
benzoic acid 5-(S)-amino-2-(S)-(1-(S)-carboxy-ethylcarbamoyl)-4-oxo-6-phenyl-hexyl ester trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: ammonium cerium (IV) nitrate / water; acetonitrile / 0.58 h / 20 °C

2.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 0.25 h / -10 °C

3.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.05 h / 20 °C

3.2: 20 °C

4.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / Inert atmosphere

With ammonium cerium (IV) nitrate; lithium hydroxide monohydrate; palladium 10% on activated carbon; water; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2011.05.108

Reference yield:

: 1322615-28-0
[1-(S)-benzyl-5-(4-(R)-benzyl-2-oxo-oxazolidin-3-yl)-4-(S)-hydroxymethyl-2,5-dioxo-pentyl]-(4-methoxy-benzyl)-carbamic acid benzyl ester

: 1322615-33-7
benzoic acid 5-(S)-amino-2-(S)-(1-(S)-carboxy-ethylcarbamoyl)-4-oxo-6-phenyl-hexyl ester trifluoroacetate

Guidance literature:: Multi-step reaction with 5 steps

1.1: pyridine; dmap / dichloromethane / 4.5 h / 20 °C

2.1: ammonium cerium (IV) nitrate / water; acetonitrile / 0.58 h / 20 °C

3.1: lithium hydroxide monohydrate; water / tetrahydrofuran / 0.25 h / -10 °C

4.1: (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.05 h / 20 °C

4.2: 20 °C

5.1: palladium 10% on activated carbon; hydrogen / methanol / 20 °C / Inert atmosphere

With pyridine; dmap; ammonium cerium (IV) nitrate; lithium hydroxide monohydrate; palladium 10% on activated carbon; water; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2011.05.108