N-(1-H-imidazol-1-ylcarbonyl)-m-(trifluoromethyl)phenylalanine methyl ester

Base Information

Chemical Name:N-(1-H-imidazol-1-ylcarbonyl)-m-(trifluoromethyl)phenylalanine methyl ester
CAS No.:131235-52-4
Molecular Formula:C₁₅H₁₄F₃N₃O₃
Molecular Weight:341.29
Hs Code.:

Synonyms:N-(1-H-imidazol-1-ylcarbonyl)-m-(trifluoromethyl)phenylalanine methyl ester

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Chemical Property of N-(1-H-imidazol-1-ylcarbonyl)-m-(trifluoromethyl)phenylalanine methyl ester

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Technology Process of N-(1-H-imidazol-1-ylcarbonyl)-m-(trifluoromethyl)phenylalanine methyl ester

There total 6 articles about N-(1-H-imidazol-1-ylcarbonyl)-m-(trifluoromethyl)phenylalanine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 288-32-4
1H-imidazole

: 102422-54-8
m-(trifluoromethyl)phenylalanine methyl ester isocyanate

: 131235-52-4
N-(1-H-imidazol-1-ylcarbonyl)-m-(trifluoromethyl)phenylalanine methyl ester

Guidance literature:: In diethyl ether; for 2h; Heating;
DOI:10.1021/jm00157a034

Reference yield:

: 102422-51-5
diethyl (m-(trifluoromethyl)benzyl)formamidomalonate

: 131235-52-4
N-(1-H-imidazol-1-ylcarbonyl)-m-(trifluoromethyl)phenylalanine methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 37 percent / 10percent HCl / 4 h / Heating

2: 82 percent / thionyl chloride / 2 h

3: 84 percent / dioxane / Heating

4: 97 percent / diethyl ether / 2 h / Heating

With hydrogenchloride; thionyl chloride; In 1,4-dioxane; diethyl ether;
DOI:10.1021/jm00157a034

Reference yield:

: 3832-76-6
m-(trifluoromethyl)phenylalanine hydrochloride

: 131235-52-4
N-(1-H-imidazol-1-ylcarbonyl)-m-(trifluoromethyl)phenylalanine methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 82 percent / thionyl chloride / 2 h

2: 84 percent / dioxane / Heating

3: 97 percent / diethyl ether / 2 h / Heating

With thionyl chloride; In 1,4-dioxane; diethyl ether;
DOI:10.1021/jm00157a034