(E)-3-(3-(4-adamantan-1-yl-2-methylphenoxy)acrylamido)benzoic acid methylester

Base Information

Chemical Name:(E)-3-(3-(4-adamantan-1-yl-2-methylphenoxy)acrylamido)benzoic acid methylester
CAS No.:1373443-06-1
Molecular Formula:C₂₈H₃₁NO₄
Molecular Weight:445.558
Hs Code.:

Synonyms:(E)-3-(3-(4-adamantan-1-yl-2-methylphenoxy)acrylamido)benzoic acid methylester

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Chemical Property of (E)-3-(3-(4-adamantan-1-yl-2-methylphenoxy)acrylamido)benzoic acid methylester

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Technology Process of (E)-3-(3-(4-adamantan-1-yl-2-methylphenoxy)acrylamido)benzoic acid methylester

There total 6 articles about (E)-3-(3-(4-adamantan-1-yl-2-methylphenoxy)acrylamido)benzoic acid methylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.3%

: 1373443-06-1
(E)-3-(3-(4-adamantan-1-yl-2-methylphenoxy)acrylamido)benzoic acid methylester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield: 74.5%

: 4518-10-9
Methyl 3-aminobenzoate

: 1373443-33-4
(E)-3-(4-adamantan-1-yl-2-methylphenoxy)acrylic acid

: 1373443-06-1
(E)-3-(3-(4-adamantan-1-yl-2-methylphenoxy)acrylamido)benzoic acid methylester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In N,N-dimethyl-formamide; at 20 ℃; Inert atmosphere;
DOI:10.1021/jm301419d

Reference yield:

: 1414335-36-6
1-(4-methoxy-3-methyl-phenyl)-adamantane

: 1373443-06-1
(E)-3-(3-(4-adamantan-1-yl-2-methylphenoxy)acrylamido)benzoic acid methylester

Guidance literature:: Multi-step reaction with 4 steps

1: boron tribromide / dichloromethane / 2 h / -10 °C / Inert atmosphere

2: triphenylphosphine / toluene / 3 h / -10 - 115 °C / Inert atmosphere

3: lithium hydroxide monohydrate / tetrahydrofuran; water / 20 °C / Inert atmosphere

4: N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

With lithium hydroxide monohydrate; boron tribromide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; dichloromethane; water; N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm301419d