8-amino-6(N)-methyl-2-ribofuranosyl-1,2,3,5,6,7-hexaazaacenaphthylene

Base Information

• Chemical Name: 8-amino-6(N)-methyl-2-ribofuranosyl-1,2,3,5,6,7-hexaazaacenaphthylene
• CAS No.: 109947-70-8
• Molecular Formula: C₁₂H₁₅N₇O₄
• Molecular Weight: 321.296
• Mol file: 109947-70-8.mol

Synonyms:8-amino-6(N)-methyl-2-ribofuranosyl-1,2,3,5,6,7-hexaazaacenaphthylene

Chemical Property of 8-amino-6(N)-methyl-2-ribofuranosyl-1,2,3,5,6,7-hexaazaacenaphthylene

Chemical Property:

• Vapor Pressure: 1.37E-21mmHg at 25°C
• Boiling Point: 717.2°Cat760mmHg
• Flash Point: 387.5°C
• PSA: 158.09000
• Density: 2.19g/cm³
• LogP: -2.16320

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-amino-6(N)-methyl-2-ribofuranosyl-1,2,3,5,6,7-hexaazaacenaphthylene

There total 5 articles about 8-amino-6(N)-methyl-2-ribofuranosyl-1,2,3,5,6,7-hexaazaacenaphthylene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

8-amino-4-hydrazino-6-N-methyl-2-β-D-ribofuranosyl-1,2,3,5,6,7-hexaazaacenaphthylene (129572-02-7) → 8-amino-6-N-methyl-2-(β-D-ribofuranosyl)-1,2,3,5,6,7-hexaazaacenaphtylene (109947-70-8)

Guidance literature:

With mercury(II) oxide; In ethanol; N,N-dimethyl-formamide; for 4h; Heating;

DOI:10.1021/jm00174a012

Reference yield:

8-amino-6-methyl-4-methylthio-2-(β-D-ribofuranosyl)-2,6-dihydro-1,2,3,5,6,7-hexaacenaphthylene (125284-49-3) → 8-amino-6-N-methyl-2-(β-D-ribofuranosyl)-1,2,3,5,6,7-hexaazaacenaphtylene (109947-70-8)

Guidance literature:

With nickel;

DOI:10.1016/S0040-4039(00)99223-2

Reference yield:

8-amino-4-(methylsulfonyl)-6-N-methyl-2-β-D-ribofuranosyl-1,2,3,5,6,7-hexaazaacenaphthylene (129572-01-6) → 8-amino-6-N-methyl-2-(β-D-ribofuranosyl)-1,2,3,5,6,7-hexaazaacenaphtylene (109947-70-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 95 percent / hydrazine / ethanol; H₂O / 1.5 h / Heating

2: 43 percent / yellow HgO / dimethylformamide; ethanol / 4 h / Heating

With mercury(II) oxide; hydrazine; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1021/jm00174a012

upstream raw materials:

8-amino-6-methyl-4-methylthio-2-(β-D-ribofuranosyl)-2,6-dihydro-1,2,3,5,6,7-hexaacenaphthylene

8-amino-4-hydrazino-6-N-methyl-2-β-D-ribofuranosyl-1,2,3,5,6,7-hexaazaacenaphthylene

1-(β-D-Ribofuranosyl)-3-cyano-4,6-dimethylmercaptopyrazolo<3,4-d>pyrimidine

3-cyano-4-(1-methylhydrazino)-6-methylthio-1-(β-d-ribofuranosyl)-1H-pyrazolo<3.4-d>pyrimidine