-3,3-dimethylpropionyl>-O-methyltyrosinyl>-L-histidine amide of (1'R,2'S,5S)-5-<2'-amino-3'cyclohexyl-1'-hydroxypropyl>-3-ethyloxazolidin-2-one

Base Information

Chemical Name:-3,3-dimethylpropionyl>-O-methyltyrosinyl>-L-histidine amide of (1'R,2'S,5S)-5-<2'-amino-3'cyclohexyl-1'-hydroxypropyl>-3-ethyloxazolidin-2-one
CAS No.:1054759-30-6
Molecular Formula:C₄₃H₅₉N₇O₉
Molecular Weight:817.983
Hs Code.:

<N-<3-<(benzyloxycarbonyl)amino>-3,3-dimethylpropionyl>-O-methyltyrosinyl>-L-histidine amide of (1'R,2'S,5S)-5-<2'-amino-3'cyclohexyl-1'-hydroxypropyl>-3-ethyloxazolidin-2-one

Synonyms:-3,3-dimethylpropionyl>-O-methyltyrosinyl>-L-histidine amide of (1'R,2'S,5S)-5-<2'-amino-3'cyclohexyl-1'-hydroxypropyl>-3-ethyloxazolidin-2-one

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Chemical Property of -3,3-dimethylpropionyl>-O-methyltyrosinyl>-L-histidine amide of (1'R,2'S,5S)-5-<2'-amino-3'cyclohexyl-1'-hydroxypropyl>-3-ethyloxazolidin-2-one

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Technology Process of -3,3-dimethylpropionyl>-O-methyltyrosinyl>-L-histidine amide of (1'R,2'S,5S)-5-<2'-amino-3'cyclohexyl-1'-hydroxypropyl>-3-ethyloxazolidin-2-one

There total 4 articles about -3,3-dimethylpropionyl>-O-methyltyrosinyl>-L-histidine amide of (1'R,2'S,5S)-5-<2'-amino-3'cyclohexyl-1'-hydroxypropyl>-3-ethyloxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 143127-85-9
H-histidine amide of (1'R,2'S,5S)-5-(2'-amino-3'-cyclohexyl-1'-hydroxypropyl)-3-ethyloxazolidin-2-one

: 119589-35-4
N-<3-<(benzyloxycarbonyl)amino>-3,3-dimethylpropionyl>-O-methyltyrosine

: 1054759-30-6
-3,3-dimethylpropionyl>-O-methyltyrosinyl>-L-histidine amide of (1'R,2'S,5S)-5-<2'-amino-3'cyclohexyl-1'-hydroxypropyl>-3-ethyloxazolidin-2-one

Guidance literature:: With 4-methyl-morpholine; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; 1.) -23 deg C, 2 h, 2.) RT, overnight;
DOI:10.1021/jm00056a005

Reference yield:

: 7479-01-8
O-methyl-L-tyrosine methyl ester hydrochloride

: 1054759-30-6
-3,3-dimethylpropionyl>-O-methyltyrosinyl>-L-histidine amide of (1'R,2'S,5S)-5-<2'-amino-3'cyclohexyl-1'-hydroxypropyl>-3-ethyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1: 69 percent / N-methylmorpholine, DMAP, DMF / CH₂Cl₂ / 36 h / Ambient temperature

2: 93 percent / aq. LiOH / dioxane / 1 h / 0 °C

3: 48 percent / 1-hydroxybenzotriazole, N-methylmorpholine, 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDC) / dimethylformamide / 1.) -23 deg C, 2 h, 2.) RT, overnight

With 4-methyl-morpholine; dmap; lithium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N,N-dimethyl-formamide; In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00056a005

Reference yield:

: 134363-80-7
N-<3-<(benzyloxycarbonyl)amino>-3,3-dimethylpropionyl>-O-methyltyrosine methyl ester

: 1054759-30-6
-3,3-dimethylpropionyl>-O-methyltyrosinyl>-L-histidine amide of (1'R,2'S,5S)-5-<2'-amino-3'cyclohexyl-1'-hydroxypropyl>-3-ethyloxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1: 93 percent / aq. LiOH / dioxane / 1 h / 0 °C

2: 48 percent / 1-hydroxybenzotriazole, N-methylmorpholine, 1-ethyl-3-<3-(dimethylamino)propyl>carbodiimide hydrochloride (EDC) / dimethylformamide / 1.) -23 deg C, 2 h, 2.) RT, overnight

With 4-methyl-morpholine; lithium hydroxide; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1021/jm00056a005