Technology Process of (-)-(S)-2-(4-propylphenyl)indoline
There total 5 articles about (-)-(S)-2-(4-propylphenyl)indoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
(R)-3,3'-bis(2,4,6-triisopropylphenyl)binol phosphoric acid; N-(1-phenyl-ethylidene)-(3,4,5-trimethoxy-phenyl)-amine;
In
benzene;
at 20 - 50 ℃;
for 20h;
enantioselective reaction;
Molecular sieve;
Inert atmosphere;
DOI:10.1021/ja406004q
- Guidance literature:
-
Multi-step reaction with 3 steps
1: platinum(II) chloride / 1,2-dichloro-ethane / 42 h / 20 - 80 °C / Inert atmosphere
2: tin; hydrogenchloride / ethanol; water / 4 h / 20 - 90 °C / Inert atmosphere
3: N-(1-phenyl-ethylidene)-(3,4,5-trimethoxy-phenyl)-amine; (R)-3,3'-bis(2,4,6-triisopropylphenyl)binol phosphoric acid / benzene / 20 h / 20 - 50 °C / Molecular sieve; Inert atmosphere
With
hydrogenchloride; tin; (R)-3,3'-bis(2,4,6-triisopropylphenyl)binol phosphoric acid; N-(1-phenyl-ethylidene)-(3,4,5-trimethoxy-phenyl)-amine; platinum(II) chloride;
In
ethanol; water; 1,2-dichloro-ethane; benzene;
DOI:10.1021/ja406004q
- Guidance literature:
-
Multi-step reaction with 2 steps
1: tin; hydrogenchloride / ethanol; water / 4 h / 20 - 90 °C / Inert atmosphere
2: N-(1-phenyl-ethylidene)-(3,4,5-trimethoxy-phenyl)-amine; (R)-3,3'-bis(2,4,6-triisopropylphenyl)binol phosphoric acid / benzene / 20 h / 20 - 50 °C / Molecular sieve; Inert atmosphere
With
hydrogenchloride; tin; (R)-3,3'-bis(2,4,6-triisopropylphenyl)binol phosphoric acid; N-(1-phenyl-ethylidene)-(3,4,5-trimethoxy-phenyl)-amine;
In
ethanol; water; benzene;
DOI:10.1021/ja406004q
